| 张春燕,王慧云,孙珊珊.pH/温度双重敏感水凝胶的制备及质量评价[J].济宁医学院学报,2016,39(5):314-316 |
| pH/温度双重敏感水凝胶的制备及质量评价 |
| Preparation and quality evaluation of pH/temperature sensitive hydrogel |
| 投稿时间：2015-04-02 |
| DOI：10.3969/j.issn.1000-9760.2016.05.003 |
| 中文关键词: 水凝胶;温度敏感;pH敏感 |
| 英文关键词: Hydrogel;Temperature sensitive;pH sensitive |
| 基金项目:济宁医学院2013年校级科研项目（JY2013KJ012） |
| 作者 | 单位 | | 张春燕 | 济宁医学院药学院, 日照 276826 | | 王慧云 | 济宁医学院药学院, 日照 276826 | | 孙珊珊 | 济宁医学院药学院, 日照 276826 |
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| 中文摘要: |
| 目的 制备pH/温度双重敏感的水凝胶，并对其质量进行评价。方法 以N-异丙基丙烯酰胺为温敏材料、丙烯酰胺为pH敏感材料、丙烯酸铵为交联剂、过硫酸铵为引发剂、四甲基乙二胺为加速剂、十二烷基磺酸钠为乳化剂，通过悬浮聚合法制备载药水凝胶，并对其pH和温度敏感性进行考察。结果 载药水凝胶在pH6.0，温度为42℃时可快速释放药物，8h累计药物释放达90%以上。结论 该实验制备得到的载药水凝胶具有一定的pH和温度敏感性，能够根据环境的变化而表现出智能释药行为。 |
| 英文摘要: |
| Objective To prepare pH/temperature sensitive hydrogel and evaluate the quality.Methods N-isopropyl acrylamide were used as temperature sensitive material,acrylamide as pH sensitive material,ammonium acrylate as crosslinking agent,ammonium persulfate as initiator,tetramethylethylenediamine as accelerating agent and sodium dodecyl sulfonate as emulsifier to prepare the pH/temperature-sensitive hydrogel of fluorouracil by suspension polymerization.The pH sensitivity and temperature sensitivity were investigated.Results The hydrogel of fluorouracil could release drug rapidly at PH6.0 and 42℃,and the drug releasing rates could be up to 90% in 8h.Conclusion The hydrogel could exhibite different drug release rate according to the change of the environment. |
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