| 赵亚娜,冯小欢,冯芹,刘雅莉,封昱辰,张煦.骨肿瘤动物实验报告现状研究[J].济宁医学院学报,2015,(1):57-61 |
| 骨肿瘤动物实验报告现状研究 |
| The Study of the Report about Bone Tumor in Animal Experiment |
| 投稿时间：2015-01-16 |
| DOI：10.3969/j.issn.1000-9760.2015.01.016 |
| 中文关键词: 骨肿瘤;动物研究;报告 |
| 英文关键词: Bone tumor;Animal experiment;Report |
| 基金项目: |
| 作者 | 单位 | | 赵亚娜 | 兰州大学基础医学院, 甘肃兰州 730000 | | 冯小欢 | 兰州大学第二临床医学院, 兰州 730000 | | 冯芹 | 兰州大学第二临床医学院, 兰州 730000 | | 刘雅莉 | 兰州大学基础医学院, 甘肃兰州 730000 | | 封昱辰 | 兰州大学第二临床医学院, 兰州 730000 | | 张煦 | 兰州大学基础医学院, 甘肃兰州 730000 |
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| 中文摘要: |
| 目的 评价有关骨肿瘤动物实验研究的报告质量。方法 计算机检索中国知网、中国生物医学文献数据库、维普及万方数据4大中文数据库,检索时限均从2010年1月至2012年12月,检索文献语言为中文,纳入关于骨肿瘤动物实验的研究文献,再根据ARRIVE指南评估每一篇文献,最后用SPSS软件对评估所得的数据进行统计学分析。结果 最终纳入符合标准的骨肿瘤动物实验研究文献有71篇,每一篇文献的平均得分为(21.08±2.12)分,纳入文献报告质量普遍中等偏低。结论 我国骨肿瘤的动物实验报告质量总体来说很不理想,存在严重的潜在偏倚现象,未来的研究中应重视规范动物实验的设计及报告,以确保研究质量。 |
| 英文摘要: |
| Objective To evaluate the quality of the report about bone tumors in animal experiments.Methods The articles were searched about bone tumors in animal experiments at the four largest Chinese Journal database:CBM, CNKI, CBM, Wanfang from Jan. 2010 to Dec. 2012, and the language was Chinese. Each article was evaluated with ARRIVE guideline. Finally, the data acquired in the evaluation was statistically analysed with SPSS. Results There were 71 articles about bone tumors in animal experiments that met the criteria mentioned before. ARRIVE guideline was applied to evaluate those articles. Average score of the articles was 21.08±2.12. The qualities of the articles in the present work was generally middle or slightly low.Conclusion Generally, the quality of the report about bone tumor in animal experiment is quite undesirable with severe potential bias. In further studies, more attention should be paid to the design and report of animal experiments in order to guarantee the quality of the study. |
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