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| 肿瘤出芽分子机制的研究进展* |
| Advances in molecular mechanisms of tumor budding |
| 投稿时间：2023-06-13 修订日期：2024-01-15 |
| DOI： |
| 中文关键词: 肿瘤出芽;分子机制;上皮-间充质转化;EMT |
| 英文关键词: tumor budding; molecular mechanism; epithelial-mesenchymal transition；EMT |
| 基金项目:国家自然科学基金 |
| 作者 | 单位 | 邮编 | | 梁迪 | 济宁医学院临床医学院 | 272000 | | 刘艳荣* | 济宁医学院附属医院病理科 | 272000 |
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| 中文摘要: |
| 肿瘤出芽是一种存在于多种实体癌中的病理现象，通常被定义为位于肿瘤侵袭前沿的孤立的一个或多达四个癌细胞的簇。肿瘤出芽的预后价值已得到了大量证据的支持，肿瘤出芽也被视为恶性肿瘤转移的关键步骤。本篇综述的目的是将肿瘤出芽视为一个动态转化过程，并试图探究其在肿瘤细胞分离、迁移和侵袭、免疫抵抗、增殖和凋亡等具体过程中的细胞因子和分子变化，并阐明形成和维持肿瘤出芽所涉及的分子途径和基因调控通路。 |
| 英文摘要: |
| Tumor budding is a pathological phenomenon in a variety of solid cancers, which is usually defined as an isolated cluster of one or up to four cancer cells located at the front of an invasive tumor. The prognostic value of tumor budding has been supported by a lot of evidence, and tumor budding is also regarded as a key step in malignant tumor metastasis. The purpose of this review is to regard tumor budding as a dynamic transformation process, and to explore its cytokine and molecular changes in the specific processes of tumor cell separation, migration and invasion, immune resistance, proliferation and apoptosis. and clarify the molecular pathways and gene regulatory pathways involved in the formation and maintenance of tumor budding. |
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