| 班博.特发性矮小症的诊断与治疗[J].济宁医学院学报,2017,40(2):77-81,92 |
| 特发性矮小症的诊断与治疗 |
| The diagnosis and treatment of idiopathic short stature |
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| DOI：10.3969/j.issn.1000-9760.2017.02.001 |
| 中文关键词: 特发性矮小症;诊断;重组人生长激素;安全性 |
| 英文关键词: Idiopathic short stature;Recombinant human growth hormone;Strategy;safety |
| 基金项目: |
| 作者 | 单位 | | 班博 | 济宁医学院内分泌代谢病中心, 济宁 272067
济宁医学院附属医院, 济宁 272029 |
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| 中文摘要: |
| 特发性矮小症（idiopathic short stature，ISS）是一类不明病因导致的矮身材的统称，包括体质性青春发育延迟和家族性矮身材，其发病机制尚不明确。ISS诊断是一个排他性诊断，首先采用生长激素激发试验排除生长激素缺乏症，在排除营养、系统性（慢性疾病）、内分泌和综合征/染色体异常、宫内发育迟缓/小于胎龄儿等因素所致矮小可诊断为ISS。目前应用重组人生长激素治疗ISS有效，但方案尚存在争议性。本文就ISS诊断与生长激素治疗、疗效及安全性作一综述。 |
| 英文摘要: |
| Idiopathic short stature is a kind of unknown pathogenesis disease,including the constitutional delayed puberty and familial short stature.Because its pathogenesis is not yet clear,it is idiopathic.The diagnosis of ISS is an exclusive diagnosising the growth hormone provocative tests to rule out the growth hormone deficiency at first,and then to rule out the nutrition,systemic (chronic) disease,endocrine and syndrome/chromosomal abnormalities,intrauterine retarded/ small for gestational age infant and other factors caused by short can be diagnosed with ISS.At present,the application of recombinant human growth hormone treatment of idiopathic short program is still controversial.So this review summarizes the strategy and safety of growth hormone treatment in idiopathic short stature. |
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