| 姚楚晨.肝硬化门静脉血栓形成的危险因素及其对预后的影响分析[J].济宁医学院学报,2016,39(5):328-331 |
| 肝硬化门静脉血栓形成的危险因素及其对预后的影响分析 |
| Clinical risk factors and impact analysis of prognosis and outcome in liver cirrhosis patients with portal vein thrombosis |
| 投稿时间：2016-08-17 |
| DOI：10.3969/j.issn.1000-9760.2016.05.007 |
| 中文关键词: 肝硬化;门静脉血栓;风险因素;预后 |
| 英文关键词: Jver cirrhosis;Portal vein thrombosis;Risk factor;Prognosis |
| 基金项目: |
| 作者 | 单位 | | 姚楚晨 | 徐州医科大学附属医院, 徐州 221004 |
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| 中文摘要: |
| 目的 观察肝硬化患者门静脉血栓（PVT）形成的危险因素及其对预后的影响。方法 选取101例肝硬化患者为对象，其中51例肝硬化患者发生PVT为PVT组，50例肝硬化患者未发生PVT为对照组，对PVT形成的临床危险因素及预后进行分析。结果 PVT组腹水、腹痛、上消化道出血的发生率显著高于对照组，差异有统计学意义（P<0.05）；PVT组的血红蛋白含量与对照组相比显著降低，血小板计数、凝血酶原时间、D-二聚体和门静脉宽度显著升高（P<0.05）；Logistic回归分析显示：D-二聚体、血小板、Child Pugh评分和门静脉宽度差异有统计学意义（P<0.05）；PVT组患者均经电话随访询问预后情况，根据结果分为死亡组和生存组，结果显示：死亡组患者的Child Pugh评分较生存组高（P<0.05）。结论 D-二聚体、血小板、Child Pugh评分和门静脉宽度是肝硬化患者PVT形成的危险因素，Child Pugh评分过高提示肝硬化门静脉血栓形成患者预后不良。 |
| 英文摘要: |
| Objective To investigate the clinical risk factors and impact of prognosis in liver cirrhosis patients with portal vein thrombosis.Methods 101 cases of liver cirrhosis patients were selected as the object of study (51 cases liver cirrhosis patients with PVT as the PVT group,50 liver cirrhosis patients without PVT as control group).The clinical risk factors and impact of prognosis of the PVT formation were analyzed.Results Compared with the control group,the incidence of ascites,stomachache and upper gastrointestinal bleeding significantly increased in the PVT group (P<0.05).The content of hemoglobin with the PVT group significantly decreased compared with the control group (P<0.05).The blood platelet count,prothrombin time,D-dimer and portal vein width of the PVT group significantly increased (P<0.05).Logistic regression model showed that D-dimer,blood platelet count,Child Pugh grade and portal vein width has statistical significance (P<0.05).Child Pugh grade of dead group was higher than survival group(P<0.05).Conclusion D-dimer,blood platelet count,Child Pugh grade and portal vein width was the risk factors of liver cirrhosis patients with PVT.High Child Pugh grade showed poor prognosis with liver cirrhosis patients with PVT. |
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