| 毛旭艳,侯士峰.3D打印生物材料的研究进展[J].济宁医学院学报,2016,39(1):64-69 |
| 3D打印生物材料的研究进展 |
| Recent advances in 3D printing of biomaterials |
| 投稿时间：2015-05-28 |
| DOI：10.3969/j.issn.1000-9760.2016.01.015 |
| 中文关键词: 3D打印;组织工程;生物材料;支架 |
| 英文关键词: 3D printing;Tissue engineering;Biomaterials;Scaffold |
| 基金项目:国家自然科学基金(21175059) |
| 作者 | 单位 | E-mail | | 毛旭艳 | 济宁医学院生物纳米技术与医学工程研究所, 济宁 272067 | | | 侯士峰 | 济宁医学院生物纳米技术与医学工程研究所, 济宁 272067 | hou123@ymail.com |
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| 中文摘要: |
| 3D打印能够根据病人的具体解剖数据, 通过计算机设计制造复杂的生物医学装置。3D打印已经慢慢发展创造独一无二的装置、植入物、组织工程支架、诊断平台和药物输送系统。近年来由于3D打印机的广泛使用, 发展了结合干细胞与再生医学三维支架的个性化定制等新的方向。3D打印可常规应用于复杂的组织再生(如骨、软骨、肌肉、血管和颅颌面复杂的神经)和复杂的三维微结构复杂的器官(如肝、淋巴器官)。本文主要介绍了近几年3D打印组织工程生物材料方面的研究进展, 来说明3D打印应用于组织工程学等方面的进步。 |
| 英文摘要: |
| 3D printing promises to produce complex biomedical devices according to computer design using patient-specific anatomical data.Since its initial use as pre-surgical visualization models and tooling molds, 3D printing has slowly evolved to create one-of-a-kind devices, implants, scaffolds for tissue engineering, diagnostic platforms, and drug delivery systems.Fueled by the recent explosion in public interest and access to affordable printers, there is renewed interest to combine stem cells with custom 3D scaffolds for personalized regenerative medicine.Before 3D printing can be used routinely for the regeneration of complex tissues (e.g.bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g.liver, lymphoid organs), several technological limitations must be addressed.In this review, the major materials and technology advances within the last five years for each of the common 3D printing technologies (Three dimensional printing, fused deposition modeling, selective laser sintering, stereolithography, and 3D plotting/direct-write/bioprinting) are described.Examples are highlighted to illustrate the progress of each technology in tissue engineering, and key limitations are identified to motivate future research and advance this fascinating field of advanced manufacturing. |
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