| 吴允刚,李晓瑜,庞太忠,杨欣欣,张辉.阻塞性睡眠呼吸暂停低通气综合征患者手术前后血清瘦素的变化[J].济宁医学院学报,2015,(4):254-257 |
| 阻塞性睡眠呼吸暂停低通气综合征患者手术前后血清瘦素的变化 |
| Changes of leptin in patients with obstructive sleep apnea-hypopnea syndrome before and after operation |
| 投稿时间：2015-03-11 |
| DOI：10.3969/j.issn.1000-9760.2015.04.007 |
| 中文关键词: 阻塞性睡眠呼吸暂停低通气综合征|瘦素|脂肪分布 |
| 英文关键词: Obstructive sleep apnea-hypopnea syndrome|Leptin|Fat distribution |
| 基金项目:济宁医学院青年基金项目,济宁市科技局基金项目(编号:2012jnfs11,13);山东省医药卫生科技发展计划项目(编号:2014ws0197);山东省自然基金项目(编号:ZR2010hl045) |
| 作者 | 单位 | | 吴允刚 | 济宁医学院附属医院, 山东济宁 272029 | | 李晓瑜 | 济宁医学院附属医院, 山东济宁 272029 | | 庞太忠 | 济宁医学院附属医院, 山东济宁 272029 | | 杨欣欣 | 济宁医学院附属医院, 山东济宁 272029 | | 张辉 | 济宁医学院附属医院, 山东济宁 272029 |
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| 中文摘要: |
| 目的 观察阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者、OSAHS术后患者及正常人血清瘦素浓度的特点和OSAHS患者脂肪分布特点。方法 选择OSAHS患者41例,OSAHS术后患者30例,正常人40人。所有的受试者均行多导睡眠监测(PSG),测量体重指数(BMI)、颈围、腰围及臀围,检测瘦素浓度,比较各组受试者瘦素浓度及各种测量结果。结果 1)OSAHS组患者血清瘦素浓度比OSAHS术后组患者及正常组要高;2)OSAHS患者中心性肥胖程度更大;3)血清瘦素水平与BMI、睡眠呼吸暂停低通气指数(AHI)呈正相关,与最低血氧饱和度呈负相关。结论 OSAHS患者血清瘦素浓度比正常人高,手术后OSAHS患者血清瘦素浓度降低,OSAHS患者脂肪分布呈向心性分布,表现为颈围及腰围较大。 |
| 英文摘要: |
| Objective The study was designed to investigate changes of serum leptin concentration as well as the figure of fat distribution between the normal group,the OSAHS patients before and after operation.Methods 41 OSAHS patients,30 OSAHS patients after operation and 40 healthy people were selected as study objects.Indicators of every research object including polysomnography (PSG),body mass index (BMI),and neck/waist/hip circumferences were measured.In addition,the concentration of leptin was measured at the end of sleep monitoring in the morning.Results 1)The group of OSAHS patients before operation had more higher degree of central obesity compared with postoperative group and normal control group.2)Serum leptin concentration of OSAHS was higher than the patients after operation and normal control group.3)Leptin level was positively correlated with body mass index (BMI)and apnea hypopnea index (AHI),negatively correlated with the lowest oxygen saturation.Conclusion The serum leptin concentration was higher in OSAHS patients than normal people,and declined after operation.OSAHS patients showed central distribution of fat. |
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