| 赵明,王为东,李玉军.肝细胞肝癌患者CD147P53的表达及临床意义[J].济宁医学院学报,2012,(5):347-349 |
| 肝细胞肝癌患者CD147P53的表达及临床意义 |
| Expression and clinical significance of CD147 and P53 in Hepatocellular carcinoma(HCC) |
| 投稿时间：2012-06-21 |
| DOI：10.3969/j.issn.1000-9760.2012.05.012 |
| 中文关键词: 肝细胞肝癌;CD147;P53;组织芯片;免疫组织化学 |
| 英文关键词: Hepatocellular carcinoma;CD147;P53;Tissue microarray;Immunohistochemistry |
| 基金项目: |
| 作者 | 单位 | | 赵明 | 蒙阴县人民医院, 山东蒙阴 276200 | | 王为东 | 蒙阴县人民医院, 山东蒙阴 276200 | | 李玉军 | 青岛大学医学院附属医院, 山东青岛 266071 |
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| 中文摘要: |
| 目的 探讨细胞外基质蛋白诱导因子(CD147)和P53在肝细胞肝癌(HCC)中的表达及其临床意义。方法 采用组织芯片技术和免疫组织化学方法检测CD147和P53在272例肝细胞肝癌中的表达。结果 在272例HCC中,CD147的表达与组织学分级、临床分期、术后无瘤生存时间、肿瘤的直径、脉管或/和门静脉癌栓相关,与其它指标无关(P>0.05)。P53在HCC中的表达与术后无瘤生存时间、组织学分级、肝被膜浸润、血中AFP含量及淋巴结转移有关,差异具有统计学意义(P<0.05或0.01),与其它指标无关(P均>0.05);HCC组织中CD147 阳性表达患者与阴性患者比较,中位复发时间和中位生存时间均缩短,差异具有统计学意义(χ2=41.507,P=0.000;χ2=36.636,P=0.000); HCC组织中P53阳性表达患者与阴性患者比较,中位复发时间和中位生存时间均缩短,差异具有统计学意义(χ2=10.046,P=0.002;χ2=10.279,P=0.001.),两者之间无相关性(r=0.007,P=0.914)。结论 HCC中CD147和P53的阳性表达与肿瘤的临床预后密切相关,且两者均可作为HCC预后不良的判断因子。 |
| 英文摘要: |
| Objective To investigate the expression of CD147 and P53 and their clinical significance in HCC.Methods The expression of CD147 and P53 was determined by tissue microarray and immunohistochemistry(IHC)in 272 cases of HCC.Results The positive expression of CD147 were closely correlated to the histological grade, the TNM clinical stage, the survival months with no tumor after operation, the diameter of tumor and the embolus of cancer in aqueduct or portal vein, but not to the other marker(P>0.05).The expression of P53 in HCC were closely correlated to the survival months with no tumor after operation, the histological grade, the involucrum invasion in liver, the quantity of AFP in blood and lymph node metastasis, but not to other marker(P>0.05).Among the patients of positive expression of CD147, their middle replasing months and middle survival months were shorter and had closely correlation(χ2=41.507, P=0.000;χ2=36.636, P=0.000)compared with the patients of negative expression.And among the patients of positive expression of P53, their middle replasing months and middle survival months were shorter and have closely correlation(χ2=10.046, P=0.002;χ2=10.279, P=0.001) compared with the patients of negative expression.The expression of CD147 had no correlation with the expression of P53(r=0.007, P=0.914).Conclusion The positive expression of CD147 and P53 closely correlate with the clinical prognosis of HCC and a poor prognisis of HCC probably. |
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