| 张文文,叶翎.急性白血病患者血清MCP-1 sIL-2R的检测及临床意义[J].济宁医学院学报,2012,(1):31-32,35 |
| 急性白血病患者血清MCP-1 sIL-2R的检测及临床意义 |
| Expression and clinical significance of MCP-1、sIL-2R in serum of acute leukemia |
| 投稿时间：2011-12-23 |
| DOI：10.3969/j.issn.1000-9760.2012.01.009 |
| 中文关键词: 急性白血病|血清|可溶性白细胞介素2受体|单核细胞趋化蛋白-1 |
| 英文关键词: Acute Leukemia;Serum;Monocyte Chemoattractant Protein 1;Solvable Interleukin-2 Receptor |
| 基金项目: |
| 作者 | 单位 | | 张文文 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011
济南大学山东省医学科学院医学与生命学院, 山东济南 250062 | | 叶翎 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 |
|
| 摘要点击次数: 5178 |
| 全文下载次数: 986 |
| 中文摘要: |
| 目的 探讨急性白血病(Acute Leukemia,AL)患者血清中单核细胞趋化蛋白-1(Monocyte Chemoattractant Protein 1,MCP-1)、可溶性白细胞介素2受体(Solvable Interleukin-2 Receptor,sIL-2R)的表达及临床意义。方法 采用双抗夹心酶联免疫吸附试验(ELLSA)法,动态测定40例初治AL患者血清中MCP-1、sIL-2R的水平,以20名正常者为对照组。结果 初治AL患者血清MCP-1、sIL-2R表达较正常组明显升高(P<0.05);经化疗完全缓解(CR)患者血清中sIL-2R水平较化疗前明显降低,但仍高于正常对照组,完全缓解患者血清中MCP-1水平较化疗前无明显变化(P>0.05),复发患者sIL-2R水平再次升高,复发患者MCP-1水平降低。结论 动态监测MCP-1、sIL-2R含量变化有助于预测AL患者的病情变化及评估预后。 |
| 英文摘要: |
| Objective To study the expression and Clinical Significance of Monocyte Chemoattractant Protein (MCP-1), Solvable Interleukin-2 Receptor (sIL-2R) in Serum of Acute Leukemia(AL).Methods The serum levels of MCP-1, sIL-2R were dynamically determined with enzyme-linked immunosorbent assay(ELLSA) in 40 newly diagnosed patients with acute leukemia.Control group was consisted of 20 healthy individuals.Results In 40 newly diagnosed patients, the expression of MCP-1, sIL-2R were significantly higher than that in control group (P<0.05), and sIL-2R decreased after complete remission(CR) but was still higher than that in control group.However, in relapsed patients it elevated again;The expression of MCP-1 was not significantly different than that in CR patients (P>0.05), but in relapsed patients it lowered.Conclusion Dynamically determined the expression of MCP-1, sIL-2R cloud help assess the seriousness of the disease and the prognostic judgment in AL patients. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
|
|
|
