| 李爽,李坤,张跃兵.电休克治疗抑郁的细胞因子机制:临床应用新思路[J].济宁医学院学报,2025,48(2):181-184 |
| 电休克治疗抑郁的细胞因子机制:临床应用新思路 |
| Cytokine mechanisms of electroconvulsive therapy for antidepressant treatment: new clinical application insights |
| 投稿时间：2024-09-10 |
| DOI：10.3969/j.issn.1000-9760.2025.02.017 |
| 中文关键词: 抑郁症;电休克治疗;细胞因子;免疫炎症;生物标志物 |
| 英文关键词: Depression;Electroconvulsive therapy;Cytokines;Immune inflammation;Biomarkers |
| 基金项目:山东省戴庄医院团队项目 |
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| 中文摘要: |
| 抑郁症是一种常见的精神疾病,其病理机制尚未完全明了。细胞因子假说为解释抑郁症提供了一种免疫炎症视角,指出细胞因子在抑郁症发病过程中扮演关键角色。电休克治疗(electroconvulsive therapy,ECT)是一种针对严重抑郁症患者较为有效的治疗方法,尽管ECT的确切作用机制仍有待进一步研究,但现有研究表明,细胞因子在ECT过程中可能起到重要作用。本文综述了细胞因子与抑郁症的联系及ECT对其的调节作用。细胞因子参与抑郁症的神经炎症、内分泌轴紊乱及神经可塑性下降等病理过程。ECT通过调节细胞因子,影响下丘脑-垂体-肾上腺素(hypothalamic-pituitary-adrenal,HPA)、肠道微生物及脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)轴等神经机制,发挥抗抑郁作用。细胞因子作为生物标志物,为ECT个性化治疗提供了新思路。基于细胞因子的个性化策略及新抗抑郁干预手段的开发,有望提高ECT的疗效和安全性,为抗抑郁治疗策略提供新视角。 |
| 英文摘要: |
| Depression is a common mental disorder,and its pathological mechanisms remain not fully understood.The cytokine hypothesis offers an immuno-inflammatory perspective to explain depression,suggesting that cytokines play a crucial role in the pathogenesis of depression.Electroconvulsive therapy (ECT) is an effective treatment for patients with severe depression.Although the exact mechanisms of ECT are yet to be fully elucidated,current research suggests that cytokines may play a key role during ECT treatment.This article reviews the association between cytokines and depression,as well as the regulatory role of ECT.Cytokines are implicated in the pathophysiological processes of depression,including neuroinflammation,disruption of the endocrine axis, and decreased neuroplasticity.ECT exerts its antidepressant effects by modulating cytokines,thereby influencing neuro-mechanisms such as the hypothalamic-pituitary-adrenal (HPA) axis,intestinal microbiota,and brain-derived neurotrophic factor (BDNF).Cytokines serve as biomarkers,providing new insights into personalized ECT treatment strategies.The development of personalized strategies based on cytokines and novel antidepressant interventions holds promise for enhancing the efficacy and safety of ECT,offering a fresh perspective on antidepressant treatment strategies. |
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