| 孔涵,林娜.Her-2阳性乳腺癌患者Ki-67表达水平与新辅助化疗敏感性及预后的关系[J].济宁医学院学报,2025,48(2):152-156 |
| Her-2阳性乳腺癌患者Ki-67表达水平与新辅助化疗敏感性及预后的关系 |
| Relationship between Ki-67 expression level and neoadjuvant chemotherapy sensitivity and prognosis in patients with Her-2 positive breast cancer |
| 投稿时间：2024-02-27 |
| DOI：10.3969/j.issn.1000-9760.2025.02.011 |
| 中文关键词: Her-2阳性乳腺癌;Ki-67;新辅助化疗;敏感性;预后 |
| 英文关键词: Her-2 positive breast cancer;Ki-67;Neoadjuvant chemotherapy;Sensitivity;Prognosis |
| 基金项目: |
| 作者 | 单位 | | 孔涵 | 济宁医学院基础医学院, 济宁 272067 | | 林娜 | 济宁医学院基础医学院, 济宁 272067 |
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| 中文摘要: |
| 目的 探究Her-2阳性乳腺癌患者Ki-67蛋白表达水平与新辅助化疗敏感性及预后的关系。方法 选取新疆医科大学第一附属医院2018年1月至2021年10月113例行2～8个周期TCbHP或THP药物新辅助化疗的Her-2阳性乳腺癌患者。化疗敏感性分析应用logistic回归,利用ROC曲线分析评估危险因素预测新辅助化疗敏感性的准确性。采用Kaplan-Meier生存分析法和Cox比例风险回归模型进行生存分析。结果 113例乳腺癌患者中Ki-67蛋白阳性率为57.52%;Ki-67蛋白阳性新辅助化疗敏感率为95.38%,高于Ki-67蛋白阴性患者的68.75%,差异有统计学意义(P＜0.05);乳腺癌患者Ki-67蛋白阴性表达会降低患者新辅助化疗的敏感性(P＜0.05)。Kaplan-Meier生存分析法及Cox回归分析显示,Ki-67蛋白表达、组织学分级、淋巴结转移对无进展生存期有影响。结论 根据乳腺癌组织中Ki-67蛋白的表达情况可以判断新辅助化疗的敏感性。Ki-67蛋白的表达、组织学分级、淋巴结转移影响Her-2阳性乳腺癌的无进展生存时间。 |
| 英文摘要: |
| Objective To investigate the correlation between Ki-67 protein expression level and neoadjuvant chemotherapy sensitivity and prognosis in patients with Her-2 positive breast cancer. Methods A total of 113 patients with Her-2 positive breast cancer who underwent 2-8 cycles of neoadjuvant chemotherapy with TCbHP or THP drugs in the First Affiliated Hospital of Xinjiang Medical University from January 2018 to December 2021 were selected.The sensitivity analysis of chemotherapy was analyzed by logistic regression,and the accuracy of risk factors in predicting sensitivity to neoadjuvant chemotherapy was evaluated by ROC curve analysis.Kaplan-Meier survival analysis and Cox proportional risk regression model were used for survival analysis. Results The positive rate of Ki-67 protein in 113 patients with breast cancer was 57.52%.Sensitivity rate of Ki-67 protein positive neoadjuvant chemotherapy was 95.38%,higher than 68.75% in Ki-67 negative patients,and the difference was statistically significant (P＜0.05).Negative expression of Ki-67 protein in breast cancer patients decreased the sensitivity of neoadjuvant chemotherapy (P＜0.05).Kaplan-Meier survival analysis and Cox regression analysis showed that Ki-67 protein expression,histological grade and lymph node metastasis had effects on progression-free survival. Conclusion The sensitivity of neoadjuvant chemotherapy can be predicted by the expression of Ki-67 protein in breast cancer tissues. Ki-67 protein expression,histological grade and lymph node metastasis affect progression-free survival of Her-2 positive breast cancer. |
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