| 靳研,梁秋华.自噬在骨质疏松症发病中的作用[J].济宁医学院学报,2025,48(1):88-91 |
| 自噬在骨质疏松症发病中的作用 |
| The role of autophagy in the pathogenesis of osteoporosis |
| 投稿时间：2023-12-09 |
| DOI：10.3969/j.issn.1000-9760.2025.01.018 |
| 中文关键词: 骨质疏松症;自噬;药物;成骨细胞;破骨细胞;骨髓间充质干细胞 |
| 英文关键词: Osteoporosis;Autophagy;Medications;Osteoblasts;Osteoclasts;Bone marrow mesenchymal stem cells |
| 基金项目:国家自然科学基金青年基金(81400860) |
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| 摘要点击次数: 328 |
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| 中文摘要: |
| 骨质疏松症是由骨质流失和骨组织结构退化引发的、与衰老相关的疾病,成骨细胞的骨形成和破骨细胞的骨吸收之间的失衡已被证明是骨质疏松症发病的直接原因,骨髓间充质干细胞增殖与分化的改变在一定程度上也导致了骨质疏松症的发生。近年来的研究表明,自噬在对成骨细胞、破骨细胞和骨髓间充质干细胞的分化和正常功能过程中发挥着重要的调节作用,一系列的骨质疏松症治疗相关药物被证明是通过调控自噬来发挥其治疗骨质疏松症的作用。本文综述了国内外围绕自噬参与骨质疏松症发生、发展中的作用以及基于调控自噬的骨质疏松治疗药物,旨在为骨质疏松症的临床防治提供依据。 |
| 英文摘要: |
| Osteoporosis is a disease related to aging caused by bone loss and degradation of bone tissue structure.The imbalance between bone formation by osteoblasts and bone absorption by osteoclasts has been proven to be the direct cause of osteoporosis;In addition,changes in the proliferation and differentiation of bone marrow mesenchymal stem cells also contribute to the occurrence of osteoporosis to a certain extent.Recent studies have shown that autophagy plays an important regulatory role in the differentiation and normal function of osteoblasts,osteoclasts,and bone marrow mesenchymal stem cells;A series of drugs related to the treatment of osteoporosis have been proven to exert their therapeutic effects by regulating autophagy.This article reviews the role of autophagy in the occurrence and development of osteoporosis at home and abroad,as well as osteoporosis treatment drugs based on regulating autophagy,aiming to provide a basis for the clinical prevention and treatment of osteoporosis. |
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