| 魏博文,黄路芬.不同修饰方法对多糖结构及其免疫调节活性的影响[J].济宁医学院学报,2025,48(1):80-83 |
| 不同修饰方法对多糖结构及其免疫调节活性的影响 |
| Research progress of different modification methods on polysaccharide characterization and its immunomodulatory activity |
| 投稿时间：2023-05-11 |
| DOI：10.3969/j.issn.1000-9760.2025.01.016 |
| 中文关键词: 结构修饰;多糖;免疫调节;活性 |
| 英文关键词: Structure modification;Polysaccharide;Immunomodulation;Activity |
| 基金项目:中医药公共卫生服务补助专项全国中药资源普查项目(财社[2019]);济宁医学院大学生创新训练计划项目(CX2022095Z) |
|
| 摘要点击次数: 298 |
| 全文下载次数: 222 |
| 中文摘要: |
| 多糖是一类广泛存在于自然界的天然大分子物质,具有免疫调节、抗氧化、抗肿瘤、抗病毒及抗凝血等多种生物活性。多糖的生物活性与其结构关系密切,通过不同修饰方法改变多糖结构,是研究多糖活性提高与改变的重要手段,选择合适修饰方法是其活性研究的关键。本文主要概述了化学、生物及物理修饰方法对多糖表征及免疫调节活性的影响,包括多糖的硫酸化修饰、磷酸化修饰、基因工程技术修饰等,并对多糖结构修饰中存在的问题及应用前景进行了展望,以期为多糖修饰的深入研究及相关产品开发提供依据及参考。 |
| 英文摘要: |
| Polysaccharide is a kind of natural macromolecular substance with many biological activities,such as immune regulation,anti-oxidation,anti-tumor,anti-virus and anti-coagulation.The biological activities of polysaccharides are closely related to their structure.It is an important direction to modify the structure of polysaccharide by kinds of methods in order to study the improvement and change of polysaccharide activity.Thus,select appropriate modification method is the key process.This article mainly reviewed the chemical,biological,and physical modification methods of polysaccharides and the effects of modification methods on the characterization and the immunomodulatory activity of polysaccharides,including sulfated modification,phosphorylated modification,genetic engineering modification and so on.The problem and application prospect of polysaccharide structure modification was prospected,so as to provide a basis and reference for the future research of polysaccharide modification and the related product development. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
|
|
|
