| 曹梦杰,张驰裕,张斌,闫国贝,苏威强.D-二聚体、纤维蛋白原和F1+2对卵巢癌术后并发静脉血栓栓塞的预测价值[J].济宁医学院学报,2025,48(1):43-47 |
| D-二聚体、纤维蛋白原和F1+2对卵巢癌术后并发静脉血栓栓塞的预测价值 |
| Predictive value of D-dimer,fibrinogen and F1+2 for postoperative venous thromboembolism in ovarian cancer |
| 投稿时间：2024-09-24 |
| DOI：10.3969/j.issn.1000-9760.2025.01.008 |
| 中文关键词: D-二聚体;纤维蛋白原;凝血酶原片段1+2;卵巢癌;静脉血栓栓塞;肺栓塞 |
| 英文关键词: D-dimer;Fibrinogen;F1+2;Ovarian cancer;Venous thromboembolism;Pulmonary thromboembolism |
| 基金项目:焦作市科技局科技攻关项目(202223034) |
| 作者 | 单位 | E-mail | | 曹梦杰 | 河南理工大学第一附属医院检验科, 焦作 454000 | | | 张驰裕 | 河北医科大学第二医院眼科, 石家庄 050000 | | | 张斌 | 河南理工大学第一附属医院检验科, 焦作 454000 | | | 闫国贝 | 河南理工大学第一附属医院检验科, 焦作 454000 | | | 苏威强 | 河南理工大学第一附属医院血管外科, 焦作 454000 | suweiqiang0370@126.com |
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| 中文摘要: |
| 目的 探究卵巢癌术后并发静脉血栓栓塞(VTE)患者D-二聚体、纤维蛋白原(FBG)和凝血酶原片段1+2(F1+2)变化及临床意义。方法 回顾性分析2021年1月—2023年12月我院收治的99例卵巢癌患者,根据是否发生VTE将患者分为VTE组和对照组(未发生VTE患者),分析并统计两组患者的临床数据。Spearman相关分别分析D-二聚体与FBG和F1+2的相关性;二元logistics回归分析卵巢癌术后并发VTE的影响因素;受试工作者(ROC)曲线分析D-二聚体、FBG和F1+2对于卵巢癌发生VTE的预测价值。结果 卵巢癌术后并发VTE组红细胞[(3.49±0.47)×1012/L]、血红蛋白[(106.88±15.45) g/L]低于对照组[(3.99±0.63)×1012/L、(119.86±18.31) g/L,P＜0.05];而D-二聚体[(3.35±1.17) mg/L]、FBG[(3.85±0.21) g/L]、F1+2[(267.44±62.18) pmol/L]均高于对照组[(0.45±0.11) mg/L、(2.90±0.14) g/L、(186.52±45.61) pmol/L,P＜0.05];D-二聚体与F1+2呈正相关(r=0.433,P＜0.05);二元logistic回归分析结果显示D-二聚体(OR=2.485,95%CI=1.428～4.322)、FBG(OR=2.376,95%CI=1.011～5.540)和F1+2(OR=1.015,95%CI=1.001～1.03)为卵巢癌术后并发VTE的独立危险因素;D-二聚体、FBG和F1+2预测卵巢癌术后并发VTE的曲线下面积分别为0.896、0.689、0.841;D-二聚体联合F1+2的AUC为0.911。结论 卵巢癌术后并发VTE患者的D-二聚体、FBG和F1+2水平升高,且异常升高均为VTE发生的独立危险因素,这些指标对VTE的发生均有预测价值,联合三者的预测价值更高。 |
| 英文摘要: |
| Objective To explore the changes and clinical significance of D-dimer,fibrinogen (FBG) and prothrombin fragment 1+2 (F1+2) in patients with postoperative venous thromboembolism (VTE) after ovarian cancer surgery. Methods A retrospective analysis was conducted on 99 ovarian cancer patients admitted to our hospital from January 2021 to December 2023.Patients were divided into VTE group and non-VTE group according to whether VTE occurred.Clinical data of the two groups were analyzed and counted.Spearman correlation analysis was used to assess the relationships between D-dimer and FBG and F1+2 respectively.Binary logistics regression analyzsis was performed to identify risk factors affecting VTE in ovarian cancer.Receiver operating charaoteristic (ROC) curve analyzed the predictive value of D-dimer,FBG and F1+2 for VTE in ovarian cancer. Results In the DTE group,the red blood cells [(3.49±0.47)×1012/L] and hemoglobin [(106.88±15.45) g/L] were lower than those in the control group [(3.99±0.63)×1012/L,(119.86±18.31) g/L,P＜0.05];Meanwhile the D-dimer [(3.35±1.17) mg/L],FBG[(3.85±0.21) g/L],F1+2[(267.44±62.18) pmol/L] are higher than the control group [(0.45±0.11) mg/L,(2.90±0.14) g/L,(186.52±45.61) pmol/L,P＜0.05];D-dimer was positively associated with F1+2,(r=0.433,P＜0.05);The binary logistic regression analysis showed that D-dimer (OR=2.485,95%CI=1.428～4.322),FBG(OR=2.376,95%CI=1.011～5.540) and F1+2 (OR=1.015,95%CI=1.001～1.03) is an independent risk factor for concurrent VTE after ovarian cancer surgery;The area under the curve of D-dimer,FBG and F1+2 for predicting concurrent VTE after ovarian cancer surgery was 0.896,0.689 and 0.841,respectively;The AUC of the D-dimer in combination with F1+2 was 0.911. Conclusion sThe levels of D-dimer,FBG and F1+2,and the abnormal increase are all independent risk factors for VTE.These indicators have predictive value for the occurrence of VTE,and the predictive value of combining the three is higher. |
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