|
| 3D生物打印骨组织工程支架生物墨水的种类及其在骨缺损治疗中的应用 |
| Types of 3D bioprinted bone tissue engineering scaffold bioink and its application in the treatment of bone defects |
| 投稿时间：2024-03-21 修订日期：2025-04-15 |
| DOI： |
| 中文关键词: 3D生物打印;复合材料;骨组织工程支架;骨缺损 |
| 英文关键词: 3D bioprinting; composite materials; scaffolds for bone tissue engineering; bone defects |
| 基金项目:济宁医学院高层次科研项目培育计划（JYGC2021FKJ016）；济宁市重点研发计划基金（2021YXNS029；2022YXNS129；2024YXNSO89） |
| 作者 | 单位 | 邮编 | | 鲍勇钢 | 济宁医学院临床医学院 | 272067 | | 吴彬* | 济宁医学院附属医院骨科 | 272029 |
|
| 摘要点击次数: 8 |
| 全文下载次数: 0 |
| 中文摘要: |
| 骨缺损是创伤骨科中的一大挑战，通常由创伤、感染或肿瘤切除等因素引起，严重影响患者生活质量。随着3D生物打印技术的快速发展，复合材料在骨组织工程支架中的应用逐渐成为解决骨缺损问题的有效手段。通过3D打印技术，可以根据患者的个体化需求设计并打印定制化的骨组织支架，从而提高治疗的精准度。复合材料的应用在提高支架的力学性能、生物相容性和降解速率方面具有显著优势。本文综述了不同复合材料在3D生物打印中的应用，分析了生物陶瓷、聚合物等材料的特点及其优缺点。尽管3D生物打印技术在骨缺损修复中展现了巨大潜力，但在打印精度、材料性能匹配和临床应用中仍面临诸多挑战。未来的研究将着重解决这些问题，推动3D生物打印技术在骨缺损治疗中的广泛应用。 |
| 英文摘要: |
| Bone defects are a major challenge in trauma orthopedics, often caused by trauma, infection, or tumor resection, significantly affecting patients' quality of life. With the rapid development of 3D bioprinting technology, the application of composite materials in bone tissue engineering scaffolds has gradually become an effective solution to bone defects. Through 3D printing technology, customized bone tissue scaffolds can be designed and printed according to the individual needs of patients, thus improving the precision of treatment. The application of composite materials offers significant advantages in improving the mechanical properties, biocompatibility, and degradation rate of scaffolds. This review summarizes the application of different composite materials in 3D bioprinting, analyzing the characteristics, advantages, and disadvantages of biomaterials such as bioceramics and polymers. Despite the great potential of 3D bioprinting technology in bone defect repair, challenges remain in printing precision, material performance matching, and clinical applications. Future research will focus on addressing these issues and promoting the widespread application of 3D bioprinting technology in bone defect treatment. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
