| 司海霞.卡前列素氨丁三醇在产后出血高风险患者中的临床效果及对凝血因子的影响[J].济宁医学院学报,2024,47(3):222-225 |
| 卡前列素氨丁三醇在产后出血高风险患者中的临床效果及对凝血因子的影响 |
| Effect of carprost tromethamine on coagulation factors in patients at high risk for postpartum hemorrhage |
| 投稿时间：2024-04-02 |
| DOI：10.3969/j.issn.1000-9760.2024.03.012 |
| 中文关键词: 卡前列素氨丁三醇;高危孕妇;产后出血;凝血因子;凝血功能 |
| 英文关键词: Carprost tromethamine;High-risk pregnant women;Postpartum hemorrhage;Coagulation factors;Coagulation function |
| 基金项目:山东省医药卫生科技项目(面上项目)(2023160114321) |
| 作者 | 单位 | | 司海霞 | 济宁市妇幼保健计划生育服务中心妇产科, 济宁 272000 |
|
| 摘要点击次数: 43 |
| 全文下载次数: 30 |
| 中文摘要: |
| 目的 分析卡前列素氨丁三醇在预防高危产后出血患者中的临床效果及对凝血因子的影响。方法 选取自2016年9月—2022年9月于济宁市妇幼保健计划生育服务中心收治的118例产后出血高风险患者为研究对象,将对象随机分为观察组和对照组,各59例。对照组予以缩宫素20U静脉滴注联合米索前列醇0.6mg口服,观察组予以缩宫素20u静脉滴注联合卡前列素氨丁三醇250μg宫体注射或臀部肌肉注射。对比两组产后出血情况、凝血因子和凝血功能及平均止血时间。结果 观察组产妇2h出血量明显低于对照组(t=4.95,P＜0.001),产后24h和2h出血量差值比较无明显差别(t=0.86,P=0.39);经治疗后两组间凝血因子和凝血功能均有所改善,观察组的FⅦ、FⅧ和FⅨ明显高于对照组(P＜0.05);观察组的PT和APTT明显低于对照组,FIB明显高于对照组(P＜0.05),观察组平均止血时间明显低于对照组(t=9.79,P＜0.001)。两组产妇不良反应发生率经统计学比较,差异无统计学意义(P＞0.05)。结论 卡前列素氨丁三醇可降低产后出血高风险患者的2h产后出血量,调节凝血因子,改善凝血功能。 |
| 英文摘要: |
| Objective To analyze the clinicaleffect and effect on coagulation factors of carprost trometamol on the bed width and coagulation factors in patients with high risk of postpartum hemorrhage.Method sA total of 118 patients with high risk of postpartum hemorrhage from September 2016 to September 2022 in Jining Maternal and Child Health Care and Family Planning Service Center were randomly divided into observation group and control group,59 cases in each group.The patients in the observation group were treated with intravenous injection of 20u of uterine oxytocin plus 0.6mg misopreliol oral administration, while those in the control group were treated with intravenous injection of 20u lioxytocin plus intravenous injection of capprost trometamol 250ug intrau-terine or intramuscular injection of hip.The postpartum hemorrhage,coagulation factors,coagulation function and average hemostatic time were compared between the two groups.Results The amount of maternal bleeding at 2h in the observation group were lower than those in the control group.There was no significant difference in the comparison of the difference in blood loss between 24 hours and 2 hours postpartum.Both groups showed improvement in coagulation factors and coagulation function after treatment.FⅦ,FⅧ,FⅨ and FIB of the observation group were significantly higher than those in the control group,while PT and APTT were lower than those in the control group (P＜0.05) and the FIB was significantly higher than that of the control group (P＜0.05).The average hemostasis time of the observation group was significantly lower than that of the control group (t=9.79,P＜0.001).There was no statistically significant difference in the incidence of adverse reactions between the two groups of parturients (P＞0.05).Conclusion Carprost trometamol can reduce the rate of postpartum hemorrhage,regulate coagulation factors and improve coagulation function in patients with high risk of postpartum hemorrhage. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
|
|
|
