| 程小嫚,钱慧昌,董霄,刘健.伴非自杀性自伤成人抑郁患者静息态磁共振及临床症状[J].济宁医学院学报,2024,47(3):211-214 |
| 伴非自杀性自伤成人抑郁患者静息态磁共振及临床症状 |
| Resting-state magnetic resonance and clinical symptoms in depressed adult patients with non-suicidal self-injury |
| 投稿时间：2024-03-27 |
| DOI：10.3969/j.issn.1000-9760.2024.03.009 |
| 中文关键词: 非自杀性自伤;抑郁障碍;静息态磁共振;反刍思维;正念注意觉知 |
| 英文关键词: Non-suicidal self-injury;Major depressive disorder;Resting-state magnetic resonance rumination;Mindfulness |
| 基金项目:杭州市科技计划引导项目(20201231Y041) |
| 作者 | 单位 | E-mail | | 程小嫚 | 安徽医科大学精神卫生与心理科学学院, 合肥 230032 | | | 钱慧昌 | 中国科学院心理研究所, 北京 100101 | | | 董霄 | 安徽医科大学精神卫生与心理科学学院, 合肥 230032 | | | 刘健 | 安徽医科大学精神卫生与心理科学学院, 合肥 230032
杭州市第七人民医院教学部, 杭州 310013 | lj7037@126.com |
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| 中文摘要: |
| 目的 探究伴有非自杀性自伤(NSSI)行为的抑郁障碍(MDD)静息状态下大脑功能的激活水平及临床症状的表现水平。方法 选取发作期MDD伴NSSI患者9名,采用基于血氧水平依赖性(BOLD)信号的低频振荡幅度(ALFF)方法 进行分析,探讨伴有NSSI的MDD患者大脑的自发神经活动,并对该群体反刍思维、认知融合、正念注意觉知水平进行探讨。结果 MDD伴NSSI患者静息状态下右侧楔前叶、左侧颞下回、右侧颞中回、左侧颞上回、右侧缘上回存在正激活(T=4.500,P＜0.001),左侧枕中回、右侧背外侧额上回、右侧脑岛存在负激活(T=4.500,P＜0.001)。反刍思维与认知融合(r=0.907,P＜0.01)、正念注意觉知水平(r=-0.722,P＜0.05)存在显著相关。结论 MDD伴NSSI患者静息状态下大脑自发活动可能存在异常。 |
| 英文摘要: |
| Objective To investigate the level of activation of brain functions and the level of expression of clinical symptoms in the resting state of major depressive disorder (MDD) accompanied by non-suicidal self-injurious (NSSI) behavior.Method sNine patients with seizure-onset MDD with NSSI were selected and analyzed using the Amplitude of Low Frequency Oscillations based on Blood Oxygen Level Dependent (BOLD) signaling (ALFF) Method to explore the spontaneous neural activity in the brains of MDD patients with NSSI and to explore the level of rumination thinking,cognitive fusion,and positive attentional awareness in this group.Results Patients with MDD with NSSI had positive activation in the right precuneus,left inferior temporal gyrus,right middle temporal gyrus,left superior temporal gyrus,and right supramarginal gyrus at rest (T=4.500,P＜0.001),and negative activation in the left middle occipital gyrus,right dorsolateral superior frontal gyrus,and right insula (t=4.500,P＜0.001).There was a significant correlation between rumination and cognitive integration (r=0.907,P＜0.001),and level of positive attentional awareness (r=-0.722,P＜0.05).Conclusion sPatients with MDD with NSSI may have abnormal spontaneous brain activity in the resting state. |
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