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| 超声引导下经皮射频消融术联合TACE术治疗原发性肝癌患者的临床疗效 |
| Clinical efficacy of ultrasound-guided percutaneous radiofrequency ablation combined with TACE in the treatment of primary liver cancer |
| 投稿时间：2024-02-29 修订日期：2024-03-05 |
| DOI： |
| 中文关键词: 射频消融术；TACE术；原发性肝癌；临床疗效 |
| 英文关键词: Clinical ultrasound-guided percutaneous radiofrequency ablation combined TACE treatment of primary liver cancer |
| 基金项目: |
| 作者 | 单位 | 邮编 | | 金广霞* | 济宁市公共卫生医疗中心 | 272100 | | 王雪云 | 济宁市公共卫生医疗中心 | | | 李建 | 济宁市公共卫生医疗中心 | |
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| 中文摘要: |
| 目的 探究超声下经皮射频消融术联合肝动脉栓塞术（TACE）对原发性肝癌患者临床疗效及肝功能的影响。方法 选取2019年5月～2021年6月入我院治疗的原发性肝癌患者100例，随机分为对照组和观察组，对照组为TACE单纯治疗方案患者50例，观察组超声下经皮射频消融术联合TACE术治疗患者50例。比较两组肝功能情况、临床疗效、不良反应、生存情况。结果 治疗后观察组ALT、AST、总胆红素水平及AFP水平较对照组显著降低；观察组近期临床疗效总有效率为76%， 较对照组的48%，差异有统计学意义（χ25.75，P=0.017）；观察组中位无进展生存时间（12.13±2.95）月，对照组（7.05±3.73）月，差异有统计学意义（P＜0.05）；观察组生存率均高于对照组，差异有统计学意义（P＜0.05）。结论 超声下经皮射频消融术联合TACE术治疗原发性肝癌，具有显著的临床疗效，可在一定程度上改善肝功能，具有广泛、良好的临床应用前景。 |
| 英文摘要: |
| :Objective To investigate the effect of ultrasound-guided percutaneous radiofrequency ablation and hepatic arterial embolization (TACE) on clinical efficacy and liver function in patients with primary liver cancer. Methods A total of 100 patients with primary liver cancer admitted to our hospital from May 2019 to June 2019 were randomly divided into two groups: control group and Observation Group. Fifty patients with primary liver cancer were treated with TACE only in the control group, and the other 50 patients were treated in the Observation Group, that was treated with ultrasound guided percutaneous radiofrequency ablation and TACE. The liver function, clinical efficacy, adverse reaction and survival rate were compared between the two groups. Results: After treatment, the levels of ALT, AST, total bilirubin and AFP in the observation group were significantly lower than those in the control group, and the short-term effective rate was 76% in the Observation Group, 48% in the control group, the median progression-free survival time was (12.13±2.95) months in the observation group and (7.05±3.73) months in the control group (P< 0.05) , the difference was significant (P＜0.05) . Conclusion: Ultrasound-guided percutaneous Radiofrequency ablation combined with TACE in the treatment of primary liver cancer has a significant clinical effect, can improve liver function to a certain extent, and has a broad and good clinical application prospect. |
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