文章摘要
赵考考,乔岩岩,孙秀芹,魏丽娜.三种促排卵方案对多囊卵巢综合征患者体外受精-胚胎移植助孕的治疗效果[J].济宁医学院学报,2022,45(3):208-211
三种促排卵方案对多囊卵巢综合征患者体外受精-胚胎移植助孕的治疗效果
Effects of three different COH protocols on the IVF-ET outcome of patients with polycystic ovary syndrome
投稿时间:2021-03-09  
DOI:10.3969/j.issn.1000-9760.2022.03.013
中文关键词: 多囊卵巢综合征;体外受精-胚胎移植;超长方案;拮抗剂方案;长方案
英文关键词: Polycystic ovary syndrome;In vitro fertilization-embryo transfer;GnRHα super-long protocol;GnRHA protocol;GnRHα long protocol
基金项目:济宁市重点研发计划项目(2019SMNS026)
作者单位E-mail
赵考考 济宁市第一人民医院, 济宁 272011  
乔岩岩 济宁市第一人民医院, 济宁 272011 qiaoyanyan027@163.com 
孙秀芹 济宁市第一人民医院, 济宁 272011  
魏丽娜 济宁市第一人民医院, 济宁 272011  
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中文摘要:
      目的 探讨体外受精-胚胎移植(IVF-ET)助孕中更适合多囊卵巢综合征(PCOS)不孕患者的促排卵方案。方法 回顾分析2014年4月至2020年2月我院生殖中心行IVF-ET助孕的PCOS患者资料,根据促排卵方案分为3组:超长方案组(A组),74个周期;拮抗剂组(B组),80个周期;长方案组(C组),332个周期。比较3组间患者的临床资料和妊娠相关指标。结果 3组间患者年龄、BMI、AMH、基础FSH、LH、E2、T水平,HCG日P水平,获卵数、优胚数无统计学差异(P>0.05);A组和B组较C组Gn启动剂量大,A组较B组和C组Gn总剂量、Gn天数多,A组较C组HCG日E2水平高,A组较B组和C组HCG日LH水平低,C组较B组HCG日LH水平低,差异均有统计学意义(P<0.05);3组间累计临床妊娠率及移植次数无统计学差异(P>0.05),B组较A组和C组卵巢过度刺激综合征(OHSS)发生率低,差异有统计学意义(P<0.0167)。结论 拮抗剂方案Gn总量低、时间短,且OHSS发生率低,更适合PCOS患者。
英文摘要:
      Objective To provide insights into a suitable protocol in patients with polycystic ovary syndrome(PCOS) in in vitro fertilization-embryo transfer(IVF-ET).Methods The infertile women with PCOS undergoing IVF-ET in our center from April 2014 to October 2019 were respectively analyzed.A total of 486 cycles were divided into three groups according the COH protocol:Group A:GnRHα super-long protocol group,74 cycles;Group B:GnRHA protocol group,80 cycles;Group C:GnRHα long protocol group,332 cycles.The clinical and pregnancy data after matching were analyzed between the three groups.Results There were no significant differences in age,body mass index(BMI),anti Mullerian hormone(AMH),basal follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),testosterone(T),progesterone(P) on HCG day,number of eggs obtained,and number of superior embryos among the three groups(P>0.05);Group A and group B were higher than group C in starting dose of pituitary Gn,group A was higher than group B and group C in total usage and days of Gn;group A was higher than group C in E2 level on HCG day,group A was lower than that in group B and group C in LH level on HCG day,and that in group C was lower than that in group B.The difference was statistically significant(P< 0.05);There was no significant difference in cumulative clinical pregnancy rate and transplantation times among the three groups(P>0.05),the incidence of OHSS in group B was lower than that in group A and C,and the difference was statistically significant(P< 0.0167).Conclusion Compared with GnRHα super-long protocol and GnRHα long protocol,the GnRHA protocol had fewer Gn,,shorter Gn time,and lower OHSS incidence,which was more suitable for PCOS patients.
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