何娟娟,刘立新.长链非编码RNA与心肌凋亡[J].济宁医学院学报,2022,45(1):54-58 |
长链非编码RNA与心肌凋亡 |
Long non-coding RNA and myocardial apoptosis |
投稿时间:2021-03-19 |
DOI:10.3969/j.issn.1000-9760.2022.01.012 |
中文关键词: 长链非编码RNA;心肌凋亡;心血管疾病 |
英文关键词: Long Non-Coding RNA;Myocardial apoptosis;Cardiovascular disease |
基金项目:山东省医药卫生科技发展计划项目基金(2019WSB34001) |
作者 | 单位 | E-mail | 何娟娟 | 济宁医学院临床医学院, 济宁 272013 济宁医学院附属医院, 济宁 272029 | | 刘立新 | 济宁医学院临床医学院, 济宁 272013 济宁医学院附属医院, 济宁 272029 | liulx1966@hotmail.com |
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中文摘要: |
长链非编码RNA(long non-coding RNA,lncRNA)是转录本长度超过200个核苷酸且不具有功能性蛋白质编码能力的RNA转录物,其在心血管疾病中的表达存在差异。心肌凋亡是导致多种心血管疾病的重要病理过程,lncRNA可通过多种途径影响心肌凋亡。本文就lncRNA与心肌凋亡关系的研究进展做一综述,总结lncRNA通过调节心肌细胞凋亡影响心血管疾病的机制。 |
英文摘要: |
Long non-coding RNA(LncRNA)is a kind of RNA transcript with a length of more than 200 nucleotides and no functional protein coding ability.There are differences in the expression of LncRNA in cardiovascular diseases.Myocardial apoptosis is an important pathological process leading to a variety of cardiovascular diseases.LncRNA can affect myocardial apoptosis in a variety of ways.This paper reviewed the research progress of the relationship between LncRNA and myocardial apoptosis, and summarized the mechanism of LncRNA affecting cardiovascular disease by regulating cardiomyocyte apoptosis. |
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