| 刘美兰,张俊青.GABA能信号系统与神经发育障碍[J].济宁医学院学报,2021,44(4):274-277 |
| GABA能信号系统与神经发育障碍 |
| GABAergic signaling and neurodevelopmental disorders |
| 投稿时间：2021-07-26 |
| DOI：10.3969/j.issn.1000-9760.2021.04.011 |
| 中文关键词: GABA能信号;神经发育障碍;表观遗传 |
| 英文关键词: GABAergic signal;Neurodevelopmental disorders;Epigenetic factors |
| 基金项目:2016年济宁市医疗卫生类科技计划项目（2016-59） |
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| 中文摘要: |
| γ-氨基丁酸（GABA）作为神经系统中重要的抑制性神经递质，通过GABA A型受体通道或G蛋白偶联B型受体参与多种中枢神经系统功能。本文将阐述GABA能信号系统的关键方面在神经发育障碍（neurodevelopmental disorders，NDDs）病因中的作用，为推进NDDs精确治疗提供参考。 |
| 英文摘要: |
| γ-Aminobutyric acid (GABA), as an important inhibitory neurotransmitter in the nervous system, participates in a variety of central nervous system functions through GABA A receptor channel or G protein coupled B receptor.This article will elaborate the key role of GABAergic signaling in the etiology of neurodevelopmental disorders(NDDSs), so as to provide reference for promoting the precise treatment of NDDSs. |
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