王焕南,孙一甲,张震.海绵抗肿瘤活性成分研究进展[J].济宁医学院学报,2019,42(4):271-278 |
海绵抗肿瘤活性成分研究进展 |
Recent progress in anti-tumor active metabolites from sponges |
投稿时间:2018-08-30 |
DOI:10.3969/j.issn.1000-9760.2019.04.011 |
中文关键词: 海绵;抗肿瘤活性;生物碱;萜类化合物;大环内酯 |
英文关键词: Sponges;Anti-tumor activity;Alkaloids;Terpenoids;Macrolides |
基金项目:山东省自然科学基金项目(ZR2016BL05);山东省医药卫生科技发展计划项目(2015WS0413);济宁医学院教师科研扶持基金项目(JYFC2018KJ026) |
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中文摘要: |
海绵在其长期进化过程中形成了特殊的代谢过程,产生了许多结构新颖和生物活性显著的次级代谢产物,这些次级代谢产物已成为开发海洋药物或先导化合物的重要来源。本文主要从近几年来研究者对海洋不同海绵属来源的生物碱类、萜类、大环内酯类等化合物进行综述,介绍了其化学结构和抗肿瘤活性,为海洋天然产物的开发提供一定参考。 |
英文摘要: |
Sponges have established special metabolic processes to adapt the ocean environment during the long evolvement.Many secondary metabolites have been generated from sponges with novel structures and various potent biological activities,which can be used in the development of marine drugs and lead compounds.In this review,we mainly summarized the chemical structure and antitumor activity of alkaloids,terpenoids,macrolides and other compounds from the sponges.The review aims to provide useful information for developing marine natural products. |
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