| 周洪亮,郭克建,张健,陈晓芳,张华丽,周旋.济宁地区孕中期孕妇血清学筛查指标中位数库的建立[J].济宁医学院学报,2019,42(4):267-270,278 |
| 济宁地区孕中期孕妇血清学筛查指标中位数库的建立 |
| Establishment of median database of serological screening indicators for pregnant women in the second trimester of pregnancy in Jining |
| 投稿时间：2019-05-17 |
| DOI：10.3969/j.issn.1000-9760.2019.04.010 |
| 中文关键词: 血清学筛查;中位数数据库;质量控制 |
| 英文关键词: Serological screening;Medians database;Quality control |
| 基金项目:济宁市科技助推新旧动能转换计划（2017SMNS006）；山东省自然科学基金（ZR2017PH011）；济宁医学院教师科研扶持基金项目（JY2015RW008；JY2017JS002） |
| 作者 | 单位 | E-mail | | 周洪亮 | 济宁市妇幼保健计划生育服务中心, 济宁 272000 | | | 郭克建 | 济宁市妇幼保健计划生育服务中心, 济宁 272000 | | | 张健 | 济宁市妇幼保健计划生育服务中心, 济宁 272000 | | | 陈晓芳 | 济宁市妇幼保健计划生育服务中心, 济宁 272000 | | | 张华丽 | 济宁医学院山东省出生缺陷研究与转化协同创新中心, 济宁 272067 | | | 周旋 | 济宁医学院精神卫生学院, 山东省行为医学重点实验室, 济宁 272067 | Email:zhoux_86@163.com |
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| 中文摘要: |
| 目的 根据济宁本地区2014-2016年进行产前筛查的孕中期孕妇血清学标志物甲胎蛋白（AFP）、游离β-人绒毛膜促性腺激素（freeβ-HCG）和游离雌三醇（uE3）的中位数与软件内嵌中位数对比，校正并建立本地区的中位数数据库。方法 以济宁地区3年154424份孕中期孕妇样本为目标人群，运用时间免疫荧光技术检测3项血清学标志物的浓度，经lifecycle4.0 Rev.4软件计算3年的中位数，与软件内嵌中位数计算方法同时筛查风险进行对比，利用SPSS19.0软件的非参数检验方法比较3年中位数之间的差异，运用χ2检验比较筛查结果。结果 AFP的中位数2014年与2015年两组比2016年的偏高，差异有统计学意义。freeβ-HCG、uE3的中位数2014-2016年间差异没有统计学意义。济宁地区AFP、freeβ-HCG、uE3的中位数与软件内嵌高加索人种中位数进行对比均存在偏差，其中uE3受人种的差异影响更大。经本地区中位数校正的筛查阳性率上升。结论 通过济宁地区AFP、freeβ-HCG、uE3 3个软件内嵌中位数进行本地化校正可减低血清筛查出生缺陷的假阳性率。 |
| 英文摘要: |
| Objective According to the median of serological markers AFP,free β-HCG,and uE3 of pregnant women in the second trimester of prenatal screening were conducted in Jining region in 2014-2016.The median was compared with the median in the software to correct and establish the median database in this region. Methods To study the prenatal screening of 154424 pregnant women in Jining area,the concentration of three serological markers was detected by time immunofluorescence technique.The median was calculated by lifecycle 4.0 Rev.4 software and compared with the median in the software.The difference of three-year median was compared by SPSS19.0 software non-parametric test method,and the screening results were compared by chi-square test. Results The median of AFP in 2014 and 2015 was higher than that in 2016,and the difference was statistically significant.The median values of free beta-HCG and uE3 had no statistical significance between 2014,2015 and 2016.The median values of AFP,free β-HCG and uE3 in Jining area are different from those of Caucasian population embedded in software,among which uE3 was more affected by the difference of population.The positive rate of screening by median calibration increased in this area. Conclusion The median of AFP,free β-HCG and uE3 in Jining area can be corrected to reduce false positive rate and increase true positive rate. |
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