| 陈亚男,郝延磊.MicroRNAs与阿尔茨海默病研究进展[J].济宁医学院学报,2019,42(1):42-46 |
| MicroRNAs与阿尔茨海默病研究进展 |
| Research progress on MicroRNAs and Alzheimer's disease |
| 投稿时间：2019-01-12 |
| DOI：10.3969/j.issn.1000-9760.2019.01.010 |
| 中文关键词: 阿尔茨海默病;microRNA;tau蛋白;BACE1 |
| 英文关键词: Alzheimer's disease;MicroRNA;Tau;BACE1 |
| 基金项目:国家自然科学基金面上项目（81771360）；山东省自然科学基金资助项目（ZR201702150318） |
| 作者 | 单位 | E-mail | | 陈亚男 | 济宁医学院, 济宁 272067
济宁医学院附属医院, 济宁 272029 | | | 郝延磊 | 济宁医学院, 济宁 272067
济宁医学院附属医院, 济宁 272029 | yanleihao301@live.com |
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| 中文摘要: |
| 随着老龄化进展，痴呆人群逐渐递增，而阿尔茨海默病（Alzheimer's disease）作为最常见的痴呆类型，目前病因、机制尚未完全明确，由于早期诊断的限制，大多数AD患者在疾病早期未得到正规诊治。MicroRNAs是具有基因调控功能的非编码小RNA，参与细胞发育，增殖、分化、凋亡等多种生理过程及神经退行性疾病、癌症等疾病的发生发展。研究发现，miRNA与AD相关，参与AD发病相关的tau蛋白磷酸化、BACE1、APP蛋白表达等过程。本文总结了4个重点miRNA的生物学功能与AD的相关研究进展，为明确AD的发病机制提供依据，进一步协助AD的早期诊治。 |
| 英文摘要: |
| With the progress of aging,the population of dementia is gradually increasing.Although Alzheimer's disease is the most common form of dementia,its etiology and mechanism has not been completely clear.Due to the limitations of early diagnosis methods,most AD patients have not received formal diagnosis and treatment in the early stage.MicroRNAs are noncoding small RNAs that regulate gene expression.They are involved in the various physiological processes such as cellular development,proliferation,differentiation and apoptosis,as well as the occurrence and development of neurodegenerative diseases and cancers.Studies have found that miRNA is related to AD which is involved in tau protein phosphorylation,BACE1,APP protein expression and other processes related to AD.This paper summarized the relevant research progress on the biological function of four important miRNAs and AD,so as to provide a basis for defining the pathogenesis of AD and further assist in the early diagnosis and treatment of AD. |
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