| 刘娜,李文娟.自噬与中枢神经系统疾病及小胶质细胞活化研究进展[J].济宁医学院学报,2018,41(5):358-362 |
| 自噬与中枢神经系统疾病及小胶质细胞活化研究进展 |
| Research progress in autophagy and central neurological diseases related to microglial activation |
| 投稿时间：2018-06-08 |
| DOI：10.3969/j.issn.1000-9760.2018.05.014 |
| 中文关键词: 自噬;小胶质细胞;活化;中枢神经系统疾病 |
| 英文关键词: Autophagy;Microglia;Activation;Central neurological diseases |
| 基金项目:山东省自然科学基金（ZR2017LH056）；济宁市医疗卫生科技计划项目（2016-56-74） |
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| 中文摘要: |
| 自噬是真核细胞进化中高度保守的过程，用于降解和回收利用细胞内生物大分子和受损细胞器。自噬对神经细胞的动态平衡以及其在营养缺乏时的存活至关重要，在中枢神经系统疾病的发生发展过程中也发挥重要作用。小胶质细胞是中枢神经系统介导天然免疫应答反应的主要成分，持续活化的小胶质细胞能够产生多种免疫效应分子，其介导的慢性炎症已成为神经损伤过程的重要参与者。本文将简要介绍自噬与中枢神经系统疾病相关研究进展，并针对小胶质细胞活化与自噬在中枢神经系统疾病发病机制中的作用进行讨论。 |
| 英文摘要: |
| Autophagy is a highly conserved process in eukaryotic cells,which is used to degrade and recycle the biological macromolecules and organelles in cells.Autophagy is critical to maintain the dynamic balance of nerve cells and their survival in the absence of nutrients,and plays an important role in the development of central neurological diseases.Microglia is the main component of the central nervous system,which plays an important role in immune surveillance under normal conditions.Activated microglia produces a variety of immune effector molecules mediating the chronic inflammation which has become an important participant in the process of neuronal injury.This review will briefly introduce the research progress of autophagy and central neurological diseases,and discuss the role of microglia activation and autophagy in the pathogenesis of central neurological diseases. |
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