| 高红刚,周菊华.大黄素抗炎作用及相关机制研究进展[J].济宁医学院学报,2016,39(5):348-352 |
| 大黄素抗炎作用及相关机制研究进展 |
| Advances in research on antiinflamatory activity and related mechanisms of emodin |
| 投稿时间：2016-08-07 |
| DOI：10.3969/j.issn.1000-9760.2016.05.013 |
| 中文关键词: 大黄素;抗炎作用;机制 |
| 英文关键词: Emodin;Antiinflamatory activity;Mechanism |
| 基金项目:2008年济宁医学院青年基金（077801）；2015年山东省高等学校优季青年教师国内访问学者奖励项目 |
| 作者 | 单位 | E-mail | | 高红刚 | 济宁医学院药学院, 日照 276826
鲁东大学生命科学学院, 烟台 264025 | | | 周菊华 | 济宁医学院药学院, 日照 276826
鲁东大学生命科学学院, 烟台 264025 | juhuaz@hotmail.com |
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| 中文摘要: |
| 大黄素为蒽醌类衍生物，具有利尿、舒张血管、抗菌、抗病毒、抗炎和抗癌等药理活性。关于大黄素抗炎作用的研究报道日益增多，体内和体外试验已证明大黄素对多种炎症具有调节作用。其作用机制可能为大黄素与许多炎症过程中的重要分子和炎性细胞（NF-κB、PPAR、inflammasome、SDF-1和巨噬细胞等）相互作用，通过多种途径调节炎症反应，避免过度炎症对组织的损伤。本文对近5年来大黄素抑制多种炎症的活性和相关机制进行综述，为大黄素抗炎机制的阐明及相关药物的研发提供参考。 |
| 英文摘要: |
| Objective Emodin is a natural occurring anthraquinone derivative isolated from roots,which has diuretic,vasorelaxant,anti-bacterial,anti-viral,anti-inflammatory,and anti-cancer effects in previous researches.More and more researches on the antiinflamatory activities of emodin have been reported recently.The anti-inflammatory effects of emodin have been exhibited in various in vitro as well as in vivo models of inflammation.The mechanisms may be that emodin is a pleiotropic molecule capable of interacting with several major molecular targets and cell including NF-κB,PPAR,inflammasome,SDF-1 and macrophage which are involved in inflammation.This review summarizes reported anti-inflammatory activities and mechanisms of emodin so as to provide references for the further elucidation of emodin antiinflamatory mechanisms and the development of the related drugs. |
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