| 全先高,王军,刘景,丁林,孙珊珊,王慧云.正交试验优化甲氨蝶呤-壳聚糖-蒙脱土缓释微球的制备工艺及其体外释放研究[J].济宁医学院学报,2016,39(4):237-240,244 |
| 正交试验优化甲氨蝶呤-壳聚糖-蒙脱土缓释微球的制备工艺及其体外释放研究 |
| Preparation condition optimization of Methotrexate-Montmorillonite-Chitosan Sustained-Release Microsphere by orthogonal test |
| 投稿时间：2016-03-26 |
| DOI：10.3969/j.issn.1000-9760.2016.04.003 |
| 中文关键词: 蒙脱土;壳聚糖;甲氨蝶呤;缓释微球 |
| 英文关键词: Montmorillonite;Chitosan;Methotrexate;Sustained-Release Microsphere |
| 基金项目:济宁医学院科研项目（JY2013KJ022）；济宁医学院科研项目（JY2013KJ010） |
| 作者 | 单位 | | 全先高 | 济宁医学院药学院, 日照 276826 | | 王军 | 济宁医学院药学院, 日照 276826 | | 刘景 | 济宁医学院药学院, 日照 276826 | | 丁林 | 济宁医学院药学院, 日照 276826 | | 孙珊珊 | 济宁医学院药学院, 日照 276826 | | 王慧云 | 济宁医学院药学院, 日照 276826 |
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| 中文摘要: |
| 目的 优选一种新型药物缓释体系甲氨蝶呤（MTX）-蒙脱土（MMT）-壳聚糖（Cs）载药微球的制备工艺。方法 以Cs、MMT原料，采用反相悬浮聚合法制得一种新型药物缓释体系，以载药量为评价指标，以投药比、复合材料用量、乙醇用量、油水比为影响因素，采用正交试验L9（34）设计对制备条件进行优选，利用马尔文激光粒度仪测定器粒径和电位；通过体外释放实验探讨了载药微球在同模拟肠液中释放液中的释药规律。结果 最佳制备工艺为：药比为2：1，复合材料用为30%，乙醇占总体积的1/12，油水比为5：1；最优工艺制得的载药微球平均粒径为557.4nm，载药量为31.6%，Zeta电位20.8mV。结论 采用最佳工艺制备的微球黄载药量较高，形态和粒径较均匀，该缓释体系在模拟肠液中具有明显的缓释作用。 |
| 英文摘要: |
| Objective To optimize the preparation conditions of Methotrexate-Montmorillonite-Chitosan Sustained-Release.Methods The novel drug sustained-release system was prepared with Montmorillonite and Chitosan as the carrier material,Methotrexate as a model drug.L9(34) orthogonal test was adopted to optimize the preparation conditions which was designed with four factors of lecithin to proportion of drug,the amount of composite materials,the dosage of ethanol the ratio of oil/water,and drug-loading rate.The average particle size and Zeta potential of microspheres were characterized by Malvern zetasizer nano series.And in vitro the release experiments were used to study the drug release properties of Methotrexate-Montmorillonite-Chitosan microsphere.Results Results showed that the drug loading,the average particle size and Zeta potential were 31.6%,557.4 nm and 20.8mv under the optimal conditions of the proportion of drug 2:1,the amount of composite materials 30%,the dosage of ethanol/the total volume 1/12,and the ratio of oil/water 5:1 respectively.Conclusion The microspheres under the optimal conditions of the proportion of drug has the size distribution homogeneously assumed and the good sphericity.The Methotrexate-Montmorillonite-Chitosan Sustained-Release system has obvious slow-release function in the simulated intestinal juice. |
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