| 丁林,柳青,全先高,孙珊珊,张永强.雌二醇对非离子表面活性剂囊泡粒径的影响[J].济宁医学院学报,2016,39(2):91-93 |
| 雌二醇对非离子表面活性剂囊泡粒径的影响 |
| Influence of estradiol on the encapsulation efficiency and particle size of the non-ionic niosomes |
| 投稿时间：2015-10-14 |
| DOI：10.3969/j.issn.1000-9760.2016.02.004 |
| 中文关键词: 非离子表面活性剂囊泡;雌二醇;钙黄绿素 |
| 英文关键词: Non-ionic surfacant vesicles (niosomes);Estradiol;Calcein |
| 基金项目:济宁医学院科研项目(JY2013KJ006;JY2013KJ022) |
| 作者 | 单位 | | 丁林 | 济宁医学院药学院, 日照 276826 | | 柳青 | 济宁市中医院, 济宁 272000 | | 全先高 | 济宁医学院药学院, 日照 276826 | | 孙珊珊 | 济宁医学院药学院, 日照 276826 | | 张永强 | 济宁市中医院, 济宁 272000 |
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| 中文摘要: |
| 目的 探索雌二醇与胆固醇配比对非离子表面活性剂囊泡粒径的影响。方法 选择钙黄绿素作为模型药物,采用薄膜分散法制备非离子表面活性剂囊泡,通过粒径仪测量粒径。结果 当胆固醇与雌二醇1∶1、胆固醇用量为0.03g、水化时间1.5h、超声70次(每次3s间隔3s,功率40w)时制备的非离子表面活性剂囊泡粒径最佳,大小为400nm。结论 雌二醇可作为囊泡的膜材料,为开发治疗前列腺炎靶向药物提供了依据。 |
| 英文摘要: |
| Objective To explore the effects of ratio of estradiol/cholesterol on the particle size of non-ionic surfactant vesicles.Methods Calcein was selected as a model drug,non-ionic surfactant vesicles were prepared by thin-film dispersion method,and the particle size was measured by particle size analyzer.Results The results indicated that the optimal size of non-ionic surfactant vesicles was about 400nm,when the ratio of cholesterol/estradiol was 1∶1 with a dosage of 0.03g,the preparation was hydrated for 1.5 h and treated by ultrasound 70 times (3 second each,3 seconds interval) with power of 40w.Conclusion This study demonstrated that estradiol may serve as a vesicle membrane materials,and provided a basis for the development of targeted therapies for prostatitis treatment. |
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