| 魏晓楠,白波,陈京.5-羟色胺1A受体及其二聚化研究进展[J].济宁医学院学报,2016,39(1):48-52,57 |
| 5-羟色胺1A受体及其二聚化研究进展 |
| The research progress of 5-hydroxytryptamine 1A receptor and its dimmers |
| 投稿时间：2015-11-26 |
| DOI：10.3969/j.issn.1000-9760.2016.01.012 |
| 中文关键词: G蛋白偶联受体;5-羟色胺1A受体;二聚化;精神类疾病 |
| 英文关键词: G protein-coupled receptors;5-hydroxytryptamine 1A receptor;Dimerization;Mental diseases |
| 基金项目:国家自然科学基金项目(30971081, 31271243, 81070961, 81241052);山东省自然科学基金项目(ZR2011CM027, 2012GSF11806) |
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| 中文摘要: |
| 5-羟色胺1A(5-HT1A)受体是典型的视紫红质样G蛋白偶联受体(GPCRS), 广泛分布于脑组织中, 与多种精神类疾病的发病机制密切相关, 是精神类疾病(抑郁症、慢性疼痛等)治疗的重要药物靶点。以往的研究集中于5-HT1A受体单体, 近来研究发现, 5-HT1A受体还能以二聚体的形式存在并发挥其独特的生理、药理作用。本文就5-HT1A受体与多种G蛋白偶联受体所形成的二聚体, 以及二聚化之后对相关疾病产生的作用做一简要综述, 为与5-HT1A受体相关精神疾病的研究提供新的理论基础, 为药物研发提供新的靶点。 |
| 英文摘要: |
| Objective 5-hydroxytryptamine 1A receptor (5-HT1AR), a typical rhodopsin-like G protein-coupled receptor (GPCR) is widely distributed in the brain tissue.5-HT1AR is closely related to the pathogenesis of mental illness such as depression and chronic pain which is important targets for the treatment of neurological and mental diseases.In previous studies 5-HT1AR monomer were focused.However, recent studies show that 5-HT1AR also exerts its physiological functions in the form of dimer.In this review, we summarize a brief overview about 5-HT1AR and its a variety of dimers with other GPCRS.Meanwhile, the impact of its dimers on the related diseases was also introduced which provide a new theoretical basis for treatment with 5-HT1AR related mental disorders and a new potential target for drug development. |
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