| 仲秀秀,张国安,崔文.脂联素及其受体与恶性肿瘤相关性研究进展[J].济宁医学院学报,2013,(5):336-338 |
| 脂联素及其受体与恶性肿瘤相关性研究进展 |
| Clinical research on ultrasonographic and mammographic features and molecular biology of breast cancer |
| 投稿时间：2013-08-17 |
| DOI：10.3969/j.issn.1000-9760.2013.05.009 |
| 中文关键词: 脂联素;脂联素受体;恶性肿瘤 |
| 英文关键词: Breast cancer, Ultrasonography, Mammography, Molecular biology |
| 基金项目:山东省自然科学基金(ZR2009CM070);济宁市科技发展计划(2011-31);济宁医学院青年基金(JYQ2011KM006);山东省高等学校科技计划项目(J13LK14);山东省高校优秀科研创新团队计划资助。 |
| 作者 | 单位 | | 仲秀秀 | 济南大学山东省医学科学院, 山东济南 250022
济宁医学院基础学院 | | 张国安 | 济宁医学院基础学院 | | 崔文 | 济宁医学院法医学与医学检验学院, 山东济宁 272067 |
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| 中文摘要: |
| 脂联素(adiponectin)是脂肪细胞分泌的一种多功能脂肪因子,它具有抗糖尿病、抗动脉粥样硬化、抗炎和抗肿瘤等作用。肥胖者血脂联素浓度降低,降低的脂联素水平可能是肥胖和肿瘤发生之间的联系桥梁。 |
| 英文摘要: |
| Objective To investigate the correlation clinical characteristics between the ultrasonographic and mammographic features with molecular biology such as ER, PR and CerbB-2 of breast cancer.Methods The ultrasonographic and mammographic features of 137 cases of breast cancer confirmed by histopathology were analyzed retrospectively.The indexes of ultrasonic main observation were as following:lump size, shape, internal echo, aspect ratio, halo edge and burr sign, blood flow, calcification and lymph node metastasis.The indexes of mammographic main observation were as following:breast cancer patients, lesion type, mass density, calcification and boundaries, and it was analysed the relationship with ER, PR and CerbB-2.Results 1) About the ultrasonographic features, ER and PR positive rate in tumors had spiculate margin and the boundary halo, length and breadth rate≥1 was higher than the group without spiculate margin, boundary halo and breadth rate1;CerbB-2 negative rate tumors with boundary halo was higher than the group without boundary halo;CerbB-2 positive rate in tumors with calcification was higher than the group without calcification;PR negative rate in tumors with internal necrosis was higher than the group without internal necrosis.2) About the mammographic features, ER positive rate in mass with calcification was higher than other three types;CerbB-2 positive rate in tumors with calcification was higher than the group without calcification;ER and PR positive rate in tumors with indistinct boundary was higher than the group without this sigh.Conclusion There are some correlations between breast cancer ultrasonographic and mammographic features.The imaging features can assess the biologic behavior. |
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