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| 奥氮平联合丙戊酸钠治疗颅脑外伤后躁狂状态的疗效及认知功能影响的研究 |
| Study on the efficacy and cognitive function impact of olanzapine combined with valproate in the treatment of manic states after Traumatic Brain InjuryWang Lifeng<sub>1</sub><sup>, </sup>Ma Li<sub>2</sub><sup>,</sup> Kong Jianguo<sub>3</sub><sup>, Liu Xia</sup><sub><sup>2</sup></sub> |
| 投稿时间：2026-03-17 修订日期：2026-07-21 |
| DOI： |
| 中文关键词: 颅脑外伤 躁狂 认知 奥氮平 丙戊酸钠 |
| 英文关键词: raumatic Brain Injury Mania Cognition Olanzapine Sodium Valproate |
| 基金项目:济宁市重点研发计划项目 (2023YXNS141) |
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| 中文摘要: |
| 目的 探讨奥氮平联合丙戊酸钠治疗颅脑外伤(TBI)后躁狂状态的临床疗效及其对认知功能的影响。方法 纳入2023年1月—2025年12月因TBI住院并出现躁狂症状的患者100例,按治疗方案分为单药组和联合组(奥氮平+丙戊酸钠),各50例。分别于基线期、第1周、第2周、第4周、第8周采用贝克-拉范森躁狂量表(BRMS)评估躁狂症状,采用蒙特利尔认知评估量表(MoCA)评估认知功能。采用重复测量方差分析比较两组在不同时间点的变化趋势及组别差异。结果 两组的BRMS和MoCA评分随时间明显变化,与单药组相比,联合组在改善躁狂症状及提升认知功能方面更佳(P<0.05)。结论 奥氮平联合丙戊酸钠治疗TBI后的躁狂和认知方面具有明显优势。 |
| 英文摘要: |
| Objective: To investigate the clinical efficacy of olanzapine combined with sodium valproate in the treatment of manic states after traumatic brain injury (TBI) and its effects on cognitive function. Methods: A total of 100 hospitalized patients who developed manic symptoms after TBI between January 2023 and December 2025 were enrolled and divided into a monotherapy group and a combination group (olanzapine plus sodium valproate) according to the treatment regimen, with 50 patients in each group. Manic symptoms were assessed at baseline and at weeks 1, 2, 4, and 8 using the Bech-Rafaelsen Mania Rating Scale (BRMS), and cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA). Repeated-measures analysis of variance wasused to compare changes over time and between-group differences. Results: BRMS and MoCA scores changed significantly over time in both groups. Compared with the monotherapy group, the combination group showed greater improvement in manic symptoms and cognitive function (P<0.05). Conclusion: Olanzapine combined with sodium valproate showed significant advantages in improving post-TBI mania and cognitive function. |
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