| 【Abstract】Objective: To explore the effect of frailty on depression in elderly patients with type 2 diabetes, as well as the mediating effect of resilience and the moderating effect of social network scale. Methods: From July to December of 2024, a questionnaire survey was conducted among 144 elderly patients with type 2 diabetes who were hospitalized in the Department of Endocrine Genetic Metabolism, Affiliated Hospital of Jining Medical University using the social network survey, the FRAIL scale, Connor-Davidson resilience scale, and the geriatric depression scale. SPSS 22. 0 was use for hypothesis test and correlation analysis, and SPSS PROCESS macro program was used to test the mediating effect and moderating role. Results: the social network size of elderly diabetic patients was (3.37±1.08), and the scores of resilience, frailty and depression were (30.45±6.04), 0 (0, 1) and 0 (0, 1) respectively. Resilience was positively correlated with social network size (r = 0.240, P < 0.01), and negatively correlated with frailty and depression (r = -0.202, - 0.283, both P < 0.05). Frailty was positively correlated with depression (r = 0.329, P < 0.01). Resilience had a partial mediating effect between frailty and depressive symptoms in elderly diabetic patients, with a mediating effect of 0.059 (95%CI=0.008~0.143), accounting for 22.96% of the total effect. The social network size had a significant moderating effect. For the elderly diabetic patients at low frailty level, the bigger social network size could significantly reduce the incidence of depression, while the social network scale had a relatively low moderating effect under the high level of frailty. Conclusion: Resilience played a mediating role in the frailty and depression of elderly patients with type 2 diabetes and the regulation of social network size was significant. Good resilience and large social network size can prevent depression in elderly patients with type 2 diabetes at low frailty level. |