| 宫暖燕,韦若颍,傅甜,吴沄桦,毕可红,姜国胜.IL-22在初诊急性髓系白血病患者中的表达及其对预后的影响[J].济宁医学院学报,2026,49(1):37-42 |
| IL-22在初诊急性髓系白血病患者中的表达及其对预后的影响 |
| The significance of serum IL-22 level in patients with acute myeloid leukemia |
| 投稿时间：2025-05-23 |
| DOI：10.3969/j.issn.1000-9760.2026.01.007 |
| 中文关键词: 急性髓系白血病;白细胞介素-22;微小残留病;预后;无病生存期 |
| 英文关键词: Acute myeloid leukemia;Interleukin-22;Minimal residual disease;Prognosis;Disease-free survival |
| 基金项目:山东省自然科学基金项目(ZR2021MH080)；山东省医药卫生科技项目(202411000179) |
| 作者 | 单位 | E-mail | | 宫暖燕 | 滨州医学院基础医学院免疫室, 烟台 264003 | | | 韦若颍 | 济南市儿童医院血液科, 济南 250022 | | | 傅甜 | 滨州医学院基础医学院免疫室, 烟台 264003 | | | 吴沄桦 | 滨州医学院基础医学院免疫室, 烟台 264003 | | | 毕可红 | 山东第一医科大学(山东省医学科学院)第一附属医院(山东省千佛山医院)血液内科, 济南 250000 | | | 姜国胜 | 滨州医学院基础医学院免疫室, 烟台 264003 | jiangguosh@163.com |
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| 中文摘要: |
| 目的 检测初诊急性髓系白血病(AML)患者血清IL-22水平，并探讨其临床意义。方法 采用ELISA法检测64例初诊AML患者及10例缺铁性贫血(对照组)血清IL-22水平。通过ROC曲线确定IL-22的预后临界值。分析IL-22水平与临床特征、疗效及预后的关系。采用Kaplan-Meier法进行生存分析，Cox回归模型分析预后影响因素。结果 AML患者血清IL-22水平显著高于对照组(P＜0.001)。ROC曲线确定临界值为25 pg/mL。血清IL-22＞25 pg/mL组与≤25 pg/mL组相比，完全缓解(CR)率无显著差异(P＞0.05)，但微小残留病(MRD)阳性率、复发率均显著升高(均P＜0.001)，无病生存期(DFS)和5年生存率显著降低(均P＜0.01)。生存分析显示，CR组、MRD阴性组及IL-22≤25 pg/mL组的DFS均显著延长(均P＜0.05)。Cox多因素分析证实，血清IL-22水平是影响AML患者DFS的独立危险因素(P＜0.001)。结论 初诊AML患者血清IL-22水平升高，且高水平IL-22(＞25 pg/mL)与不良预后密切关联，是AML预后的独立危险因素。 |
| 英文摘要: |
| Objective To detect the serum interleukin-22 (IL-22) levels in newly diagnosed acute myeloid leukemia (AML) patients and explore its clinical significance. Methods Serum IL-22 levels were measured by ELISA in 64 newly diagnosed AML patients and 10 iron-deficiency anemia controls.The prognostic cutoff value of IL-22 was determined by ROC curve analysis.The associations between IL-22 levels and clinical characteristics, treatment response, and prognosis were analyzed.Survival curves were plotted using the Kaplan-Meier method, and prognostic factors were evaluated by Cox regression. Results Serum IL-22 levels were significantly higher in AML patients than in controls (P < 0.001).The ROC-derived cutoff was 25 pg/mL.Compared with the IL-22≤25 pg/mL group, the IL-22 > 25 pg/mL group showed no significant difference in complete remission (CR) rate (P > 0.05), but had significantly higher rates of minimal residual disease (MRD) positivity and relapse (both P < 0.001), as well as significantly shorter disease-free survival (DFS) and lower 5-year overall survival (both P < 0.01).Survival analysis revealed that the CR group, MRD-negative group, and IL-22≤25 pg/mL group all had significantly prolonged DFS (all P < 0.05).Multivariate Cox analysis confirmed that serum IL-22 level was an independent risk factor for DFS in AML patients (P < 0.001). Conclusion Elevated serum IL-22 levels are present in newly diagnosed AML patients, and high IL-22 level (> 25 pg/mL) is closely associated with poor prognosis, serving as an independent prognostic risk factor for AML. |
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