|
| 维生素D缺乏介导2型糖尿病合并抑郁症的病理生理机制与干预靶点 |
| Vitamin D deficiency: a pathophysiological hub linking T2DM and depression and an emerging therapeutic target. |
| 投稿时间：2025-11-10 修订日期：2026-03-23 |
| DOI： |
| 中文关键词: 2 型糖尿病;抑郁症;维生素 D 缺乏;共病;病理生理机制;干预靶点 |
| 英文关键词: Type 2 Diabetes Mellitus;Depression;Vitamin D deficiency;Comorbidity;Pathophysiological mechanism;Therapeutic target |
| 基金项目:新疆维吾尔自治区自然科学基金资助项目 |
| 作者 | 单位 | 邮编 | | 王亚萍 | 新疆医科大学第七临床医学院 | 830000 | | 阿丽娅·吉力力* | 新疆医科大学第七附属医院 | |
|
| 摘要点击次数: 0 |
| 全文下载次数: 0 |
| 中文摘要: |
| 2型糖尿病（T2DM）与抑郁症共病率高，显著加重治疗难度及疾病预后，已成为全球公共卫生重大挑战。传统机制未能完全解释其共病本质。维生素D缺乏作为一个新兴的、具有多重生物学效应的共同病理生理枢纽，成为理解和管理该共病的关键切入点。维生素D通过其受体介导的抗炎、抗氧化、神经营养及免疫调节通路，同时作用于T2DM与抑郁症发病核心环节，从而构建一个统一机制框架。尽管多项观察性研究支持维生素D缺乏与共病风险显著相关，但干预性研究结果尚不一致，可能与人群异质性、研究方法的局限性等因素有关。本文系统整合现有证据，旨在为临床通过维生素D补充及综合管理改善共病预后提供理论依据，呼吁未来开展高质量及个体化治疗策略研究，以推动该领域向循证医学与实践转化。 |
| 英文摘要: |
| The high comorbidity rate between type 2 diabetes mellitus (T2DM) and depression substantially exacerbates treatment complexity and disease prognosis, posing a major global public health challenge. Traditional mechanistic models have failed to fully elucidate the shared pathophysiology underlying this comorbidity. Vitamin D deficiency, recognized as an emerging common pathophysiological hub with pleiotropic biological effects, serves as a critical entry point for understanding and managing this dual burden. Through its receptor-mediated anti-inflammatory, antioxidative, neurotrophic, and immunomodulatory pathways, vitamin D simultaneously targets core pathogenic processes in both T2DM and depression, thereby establishing a unified mechanistic framework. Although numerous observational studies robustly associate vitamin D deficiency with increased comorbid risk, interventional trial findings remain inconsistent—likely attributable to population heterogeneity and methodological constraints. This article systematically synthesizes available evidence to provide a theoretical rationale for improving comorbid outcomes via vitamin D supplementation and integrated clinical management, and underscores the urgent need for high-quality, personalized therapeutic strategies to drive the field toward evidence-based translation and clinical practice. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
