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| 分裂型人格特质在额叶-内嗅皮层功能连接与社交回避及苦恼间的中介作用：一项静息态fMRI研究 |
| Schizotypal Personality Traits Mediate the Association Between Frontal–Entorhinal Cortex Functional Connectivity and Social Avoidance and Distress: A Resting-State fMRI Study |
| 投稿时间：2025-10-30 修订日期：2025-12-30 |
| DOI： |
| 中文关键词: 分裂型人格特质；社交回避；社交苦恼；内嗅皮层；功能连接；静息态功能磁共振 |
| 英文关键词: Schizotypal personality traits; Social avoidance; Social distress; Entorhinal cortex; Functional connectivity; Resting-state functional magnetic resonance imaging (rs-fMRI) |
| 基金项目:国家自然科学基金 |
| 作者 | 单位 | 邮编 | | 张亚文 | 济宁医学院精神卫生学院 | 272002 | | 李先瑞 | 山东省戴庄医院 | | | 韩丽云 | 济宁医学院精神卫生学院 | | | 张静 | 山东省戴庄医院 | | | 韩雪雪 | 山东省戴庄医院 | | | 陈金宝 | 山东省戴庄医院 | | | 周祎 | 山东省戴庄医院 | | | 郁昊 | 济宁医学院精神卫生学院 | | | 陈敏* | 济宁医学院精神卫生学院 | 272002 |
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| 中文摘要: |
| 目的 本研究旨在探究分裂型人格特质与社交回避和社交苦恼之间的关系及其潜在的脑神经机制。方法 153名大学生完成了分裂型人格问卷简版（SPQ-B）、社交回避及苦恼量表(SAD)，并采集其静息态磁共振数据。采用Spearman等级相关分析探究分裂型人格特质与社交回避和社交苦恼之间的关系，并采用中介分析探究分裂型人格特质在脑功能连接与社交回避和社交苦恼关系中的作用。 结果 量表评分结果显示，SPQ-B总分中位数为7.00（四分位数间距4.00，11.00），社交回避评分中位数为4.00（2.00，7.00），社交苦恼评分中位数为4.00（1.00，8.00）。分裂型人格特质与社交回避（ρ=0.41, P＜0.001）及社交苦恼（ρ=0.41, P＜0.001）均呈显著正相关。功能连接分析发现，左侧额上回眶部与左侧腹侧内嗅皮层之间的功能连接与分裂型人格特质显著负相关（ρ= -0.36, P＜0.001）。中介分析显示，分裂型人格特质完全中介了功能连接对社交回避的影响（间接效应β= -0.15, 95%CI[?8.24, ?2.31]，占总效应65%）和社交苦恼的影响（间接效应β= -0.17, 95%CI[?9.12, ?3.21]，占总效应81%）。结论 左侧额上回眶部与左侧腹侧内嗅皮层之间的功能连接通过分裂型人格特质间接影响了社交行为，为理解其神经机制提供了新证据。 |
| 英文摘要: |
| Objective: This study aimed to explore the relationship between schizotypal personality traits and social avoidance and social distress, as well as their underlying neuropsychological mechanisms.
Methods: A total of 153 university students completed the Schizotypal Personality Questionnaire–Brief (SPQ-B) and the Social Avoidance and Distress Scale (SAD), and underwent resting-state functional magnetic resonance imaging. Spearman rank correlation analyses were conducted to examine the associations between schizotypal personality traits and social avoidance and social distress. Mediation analyses were performed to investigate the role of schizotypal personality traits in the relationship between brain functional connectivity and social avoidance and social distress.?
Results: Scale score analyses showed that the median SPQ-B total score was 7.00 (interquartile range [IQR]: 4.00-11.00), the median social avoidance score was 4.00 (IQR: 2.00-7.00), and the median social distress score was 4.00 (IQR: 1.00-8.00). Schizotypal personality traits were positively correlated with both social avoidance (ρ=0.41,P＜0.001) and social distress (ρ=0.41,P＜0.001). Functional connectivity analysis revealed that the connectivity between the left orbital superior frontal gyrus and the left ventral entorhinal cortex was negatively correlated with schizotypal personality traits (ρ= -0.36,P＜0.001). Mediation analyses further demonstrated that schizotypal personality traits fully mediated the effects of functional connectivity on social avoidance (indirect effect β= -0.15, 95%CI[-8.24, -2.31], accounting for 65% of the total effect) and social distress (indirect effect β= -0.17, 95%CI[-9.12, -3.21], accounting for 81% of the total effect).
Conclusion: Functional connectivity between the left orbital superior frontal gyrus (ORBSup.L) and left ventral entorhinal cortex (ENT.L) indirectly influences social behavior through schizotypal personality traits, providing new evidence for understanding its neuropsychological mechanisms. |
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