| To explore the chain mediating role of social support and self-efficacy between e-health literacy and quality of life in patients with coronary heart disease (CHD). MethodsFrom February to June 2025, convenience sampling was used to select CHD patients Keywords: Coronary heart disease; e-Health literacy; Social support; Self-efficacy; Quality of lifedescriptive analysis, univariate analysis, and Pearson correlation analysis, and Process was used for chain mediation effect analysis. Results The e-health literacy score of CHD patients was (20.84±9.47), the social support score was (10.36±2.24), the self-efficacy score was (24.10±7.80), and the quality of life score was (74.50±20.16). Pearson correlation analysis showed that e-health literacy, social support, and self-efficacy were all positively correlated with quality of life (r values were 0.464, 0.349, and 0.529, respectively; all P<0.001). Chain mediation effect analysis showed that the total effect of e-health literacy on quality of life was 1.014 (95%CI: 0.819~1.208, P<0.001); the total mediating effect of social support and self-efficacy was 0.459 (95%CI: 0.345~0.583, P<0.001), accounting for 45.27% of the total effect. Among them, the path effect of e-health literacy→social support→quality of life was 0.082 (95%CI: 0.024~0.149, P<0.01), accounting for 8.09% of the total effect; the path effect of e-health literacy→self-efficacy→quality of life was 0.314 (95%CI: 0.219~0.420, P<0.001), accounting for 30.96% of the total effect; the path effect of e-health literacy→social support→self-efficacy→quality of life was 0.064 (95%CI: 0.037~0.098, P<0.001), accounting for 1.58% of the total effect; the direct effect of e-health literacy on quality of life was 0.554 (95%CI: 0.351~0.758, P<0.001), accounting for 54.64% of the total effect.ConclusionMedical staff can build an intervention support network to enhance the e-health literacy of CHD patients, improve their social support and self-efficacy levels, and thus improve the quality of life of CHD patients.Keywords: Coronary heart disease; e-Health literacy; Social support; Self-efficacy; Quality of life |