血清H-FABP水平与急性心肌梗死患者疾病转归的关联性及其联合TEG相关参数的预测效能

李波

文章摘要

血清H-FABP水平与急性心肌梗死患者疾病转归的关联性及其联合TEG相关参数的预测效能

The association between serum H-FABP levels and the disease outcome of patients with acute myocardial infarction and the predictive efficacy of its combination with TEG-related parameters

投稿时间：2025-06-30 修订日期：2025-09-11

DOI：

中文关键词: 急性心肌梗死；疾病转归；H-FABP；TEG

英文关键词: Acute Myocardial infarction Disease outcome H-FABP; TEG

基金项目:课题基金：延安市科技计划项目（编号：2024-SFG G-201)

作者	单位	邮编
李波^*	延安大学临床医学	716000

摘要点击次数: 0

全文下载次数: 0

中文摘要:

[摘要] 目的探讨血清心型脂肪酸结合蛋白（H-FABP）水平与急性心肌梗死（AMI）患者疾病转归的相关性及其联合血栓弹力图（TEG）相关参数的诊断效能。方法选取我院2022年8月至2024年9月收治的137例AMI患者为研究对象，所有患者均接受经皮冠状动脉介入（PCI）治疗，根据PCI术后6个月是否发生主要心血管不良事件将患者分为预后良好组（102例）和预后不良组（35例）。比较两组PCI术后3d血清H-FABP水平及TEG相关参数[凝血反应时间（R）、血凝块形成时间（K）、血凝块形成速率（α角）、血凝块形成后最大振幅（MA）]，分析两者间的相关性、影响AMI患者预后的危险因素，以及血清H-FABP水平联合TEG参数对AMI患者预后不良的预测价值。结果与预后良好组相比，预后不良组PCI术后3d血清H-FABP水平、α角、MA值较高，R值、K值较低（P＜0.05）；PCI术后3d，血清H-FABP水平、α角、MA值与预后不良呈正相关，R值、K值与预后不良呈负相关（P＜0.05）；Logistic回归分析显示，校正发病至PCI时间、PCI术后3d血清CK、CK-MB、cTnI、BNP水平因素后，H-FABP水平、R值、K值、α角、MA值仍为AMI患者预后不良的影响因素（P＜0.05）；ROC曲线结果显示，PCI术后3d血清H-FABP水平联合R值、K值、α角、MA值预测AMI患者预后不良的AUC优于单一诊断。结论血清H-FABP水平与AMI患者PCI术后预后效果有关，联合TEG相关参数进行诊断，能提高临床对预后不良的预测价值。

英文摘要:

[Abstract] Objective To explore the correlation between serum cardiotype fatty acid-binding protein (H-FABP) levels and the disease outcome of patients with acute myocardial infarction (AMI), and the diagnostic efficacy of combined thromboelastography (TEG) related parameters. Methods: A total of 137 AMI patients admitted to our hospital from August 2022 to September 2024 were selected as the research subjects. All patients received percutaneous coronary intervention (PCI) treatment. The patients were divided into the good prognosis group (102 cases) and the poor prognosis group (35 cases) based on whether major adverse cardiovascular events occurred 6 months after PCI. The serum H-FABP levels and TEG-related parameters [coagulation reaction time (R), blood clot formation time (K), blood clot formation rate (α Angle), maximum amplitude after blood clot formation (MA)] three days after PCI in the two groups were compared, and the correlation between the two and the risk factors affecting the prognosis of AMI patients were analyzed. And the predictive value of serum H-FABP level combined with TEG parameters for poor prognosis in AMI patients. Results: Compared with the good prognosis group, the serum H-FABP level, α Angle and MA value were higher in the poor prognosis group 3 days after PCI, while the R value and K value were lower (P < 0.05); Three days after PCI, the serum H-FABP level, α Angle and MA value were positively correlated with poor prognosis, while the R value and K value were negatively correlated with poor prognosis (P < 0.05). Logistic regression analysis showed that after adjusting for the time from onset to PCI, and the levels of serum CK, CK-MB, cTnI, and BNP 3 days after PCI, the level of H-FABP, R value, K value, α Angle, and MA value remained the influencing factors for poor prognosis in AMI patients (P < 0.05); The results of the ROC curve showed that the AUC of serum H-FABP level three days after PCI combined with R value, K value, α Angle and MA value in predicting poor prognosis of AMI patients was superior to a single diagnosis. Conclusion: The serum H-FABP level is related to the prognostic effect of AMI patients after PCI. Combined diagnosis with TEG-related parameters can improve the predictive value of poor prognosis in clinical practice.

View Fulltext 查看/发表评论下载PDF阅读器

漂浮通知