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| 凉山地区早产儿呼吸窘迫综合征合并支气管肺发育不良的危险因素研究 |
| Study on Risk Factors of Respiratory Distress Syndrome Complicated with Bronchopulmonary Dysplasia in Premature Infants in Liangshan Area |
| 投稿时间：2025-06-10 修订日期：2025-09-11 |
| DOI： |
| 中文关键词: 早产儿；呼吸窘迫综合征；支气管肺发育不良；危险因素 |
| 英文关键词: Premature infants, Respiratory distress syndrome, Bronchopulmonary dysplasia, Risk factors |
| 基金项目:2023年度凉山州科技计划重点研发项目（23ZDYF0039） |
| 作者 | 单位 | 邮编 | | 宋丽娟* | 西昌市人民医院 | 615000 | | 罗吉平 | 西昌市人民医院 | | | 俞琼 | 西昌市人民医院 | | | 杜英 | 西昌市人民医院 | |
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| 中文摘要: |
| 目的：探索凉山地区早产儿发生呼吸窘迫综合征合并支气管肺发育不良的危险因素，为早期临床干预提供初步线索。 方法：对2022年1月-2023年12月西昌市人民医院新生儿科住院明确诊断为NRDS的早产儿共319例为研究对象，其中合并BPD的84例为病例组，其余为对照组，对其临床数据进行Logistic回归分析。 结果：单因素分析中，妊娠期高血压、妊娠期糖尿病、阴道出血、产检史、多胎妊娠、脐带异常、胎膜早破、宫颈机能不全以及宫内窘迫的差异有统计学意义(<0.05)；Logistic分析中，发现妊娠期高血压、妊娠期糖尿病、阴道出血、多胎妊娠、脐带异常、胎膜早破和宫内窘迫为发生呼吸窘迫综合征合并支气管肺发育不良的危险因素(<0.05)。 结论：确定了妊娠期高血压、妊娠期糖尿病、孕期感染、阴道出血、多胎妊娠、脐带异常、胎膜早破和宫内窘迫是引起凉山地区早产儿发生呼吸窘迫综合征合并支气管肺发育不良的高危因素。 |
| 英文摘要: |
| Objective To explore the risk factors of respiratory distress syndrome complicated with bronchopulmonary dysplasia in preterm infants in liangshan area, and to provide a basis for early clinical intervention. Methods A total of 319 preterm infants with a clear diagnosis of NRDS who were hospitalized in the Neonatal Department of Xichang People's Hospital from January 2022 to December 2023 were selected as the research subjects. Among them, 84 cases with BPD were assigned to the case group, and the rest were assigned to the control group. Logistic regression analysis was conducted on their clinical data. Result In the univariate analysis, the differences in gestational hypertension, gestational diabetes, vaginal bleeding, history of prenatal examination, multiple pregnancies, umbilical cord abnormalities, premature rupture of membranes, cervical insufficiency, and intrauterine distress were statistically significant (p<0.05); In the Logistic analysis, it was found that gestational hypertension, gestational diabetes, Infection during pregnancy, vaginal bleeding, multiple pregnancies, umbilical cord abnormalities, premature rupture of membranes and intrauterine distress were risk factors for the occurrence of respiratory distress syndrome combined with bronchopulmonary dysplasia (p<0.05). Conclusion It has been determined that gestational hypertension, gestational diabetes, vaginal bleeding, multiple pregnancies, umbilical cord abnormalities, premature rupture of membranes and intrauterine distress are high-risk factors causing respiratory distress syndrome combined with bronchopulmonary dysplasia in preterm infants in liangshan area. |
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