| 王历刚,杨柳,郑旭彤,游爱君,王雅娇,陈柳茵,邱吓花,黄碧春,圣夏,林桂娇.我国癌症患者失志综合征现状及相关因素的Meta分析[J].济宁医学院学报,2025,48(6):548-555 |
| 我国癌症患者失志综合征现状及相关因素的Meta分析 |
| A meta-analysis of the prevalence and associated factors of demoralization syndrome in Chinese cancer patients |
| 投稿时间：2024-05-16 |
| DOI：10.3969/j.issn.1000-9760.2025.06.012 |
| 中文关键词: 癌症;失志综合征;影响因素;Meta分析;循证护理 |
| 英文关键词: Cancer;Demoralization syndrome;Influencing factors;Meta-analysis;Evidence-based nursing |
| 基金项目:国家级大学生创新创业训练计划项目(202010393004);福建中医药大学2021年校管课题学科专项(X2021006-学科) |
| 作者 | 单位 | E-mail | | 王历刚 | 厦门大学附属心血管病医院护理部, 厦门 361000 | | | 杨柳 | 福建中医药大学护理学院, 福州 350122 | 94493607@qq.com | | 郑旭彤 | 中国医科大学护理学院, 沈阳 110000 | | | 游爱君 | 复旦大学附属中山医院厦门医院急诊科, 厦门 361000 | | | 王雅娇 | 厦门大学附属心血管病医院护理部, 厦门 361000 | | | 陈柳茵 | 龙岩市第二医院肿瘤内科, 龙岩 362300 | | | 邱吓花 | 龙岩医疗安全数据监控中心, 龙岩 362300 | | | 黄碧春 | 福建中医药大学护理学院, 福州 350122 | | | 圣夏 | 福建中医药大学护理学院, 福州 350122 | | | 林桂娇 | 福建中医药大学护理学院, 福州 350122 | |
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| 中文摘要: |
| 目的 系统评价我国癌症患者失志综合征的发生率及影响因素。方法 计算机检索中国知网、维普、万方、中国生物医学文献数据库、PubMed、Cochrane Library和Web of Science各中英文电子数据库建库至2023年12月23日收录的关于我国癌症患者失志综合征发生率及影响因素的研究,采用Stata 16.0软件对符合纳入标准的文献进行Meta分析。结果 共纳入26篇横断面研究,涉及5692例患者;Meta分析结果显示,我国癌症患者失志综合征总体发生率为58.1％,失志量表均分为32.39(95%CI:30.49~34.29)。影响因素涉及性别、婚姻状况、学历、年龄、付费方式、治疗方式、肿瘤分期、地理位置、面对、回避、屈服、希望、焦虑、抑郁、社会支持和生活质量16个影响因素。相关性分析显示,失志状态与面对应对方式(summary r=-0.30,95%CI:-0.44~-0.15)、回避应对方式(summary r=-0.11,95%CI:-0.17~-0.05)、社会支持水平(summary r=-0.52,95%CI:-0.59~-0.44)、希望水平(summary r=-0.51,95%CI:-0.69~-0.29)及生活质量(summary r=-0.58,95%CI:-0.77~-0.31)呈负相关,与屈服应对方式(summary r=0.52,95%CI:0.38~0.64)、焦虑(summary r=0.51,95%CI:0.41~0.61)、抑郁(summary r=0.59,95%CI:0.53~0.66)呈正相关(均P＜0.001)。结论 我国癌症患者失志综合征发生率较高,其水平与屈服应对、抑郁、焦虑及社会支持等因素存在中等强度关联。临床应优先针对这些强相关因素,对女性、无配偶、低学历、晚期肿瘤等高危人群开展早期风险评估,制定并实施个性化干预策略,以降低失志风险、提升患者生活质量。 |
| 英文摘要: |
| Objective To systematically evaluate the incidence and influencing factors of demoralization syndrome in Chinese patients with cancer. Methods A comprehensive computer search for literature about incidence and influencing factors of demoralization syndrome in Chinese patients with cancer was conducted from CNKI,VIP,WanFang Database,PubMed,Cochrane Library and Web of Science.The retrieval time was from the establishment of the databases to December 23,2023.The Stata 16.0 software was used for meta-analysis. Results A total of 26 cross-sectional studies involving 5,692 patients were included;Meta-analysis results revealed that the overall prevalence of demoralization syndrome among Chinese patients with cancer was 58.1%,with a average score of 32.39 (95%CI:30.49 to 34.29) on the loss of hope scale.Sixteen influencing factors were identified:gender,marital status,educational attainment,age,payment method,treatment modality,tumor stage,geographic location,coping style,hope,anxiety,depression,level of social support,and quality of life.Correlation analysis showed that the severity of demoralized was negatively correlated with confrontation coping (summary r=-0.30,95%CI:-0.44～-0.15),avoidance coping (summary r=-0.11,95%CI:-0.17～-0.05),social support level (summary r=-0.52,95%CI:-0.59～-0.44),hope level (r=-0.51,95%CI:-0.69～-0.29),and quality of life (r=-0.58,95%CI:-0.77～-0.31).It was positively correlated with the acquiescence coping (summary r=0.52,95%CI:0.38～0.64), anxiety (summary r=0.51,95%CI:0.41～0.61), and depression (summary r=0.59,95%CI:0.53～0.66) (all P＜0.001). Conclusion The prevalence of demoralization syndrome is high among Chinese cancer patients,with moderate-strength associations observed between its severity and factors such as yielding coping,depression,anxiety,and social support.Clinicians should prioritize addressing these strongly correlated factors by conducting early risk assessments for high-risk populations-including women,unmarried individuals,those with lower education levels,and patients with advanced-stage tumors-and implementing personalized intervention strategies to reduce the risk of loss of will and improve patients' quality of life. |
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