| 宋丽娟,罗吉平,俞琼,杜英.凉山地区早产儿呼吸窘迫综合征合并支气管肺发育不良的危险因素[J].济宁医学院学报,2025,48(5):401-405 |
| 凉山地区早产儿呼吸窘迫综合征合并支气管肺发育不良的危险因素 |
| Risk factors of respiratory distress syndrome complicated with bronchopulmonary neonatal dysplasia in premature infants in Liangshan area |
| 投稿时间：2025-06-10 |
| DOI：10.3969/j.issn.1000-9760.2025.05.004 |
| 中文关键词: 早产儿;呼吸窘迫综合征;支气管肺发育不良;危险因素 |
| 英文关键词: Premature infants;Respiratory distress syndrome;Bronchopulmonary dysplasia;Risk factors |
| 基金项目:2023年度凉山州科技计划重点研发项目(23ZDYF0039) |
| 作者 | 单位 | E-mail | | 宋丽娟 | 西昌市人民医院新生儿科, 西昌, 615000 | | | 罗吉平 | 西昌市人民医院新生儿科, 西昌, 615000 | 812463523@qq.com | | 俞琼 | 西昌市人民医院新生儿科, 西昌, 615000 | | | 杜英 | 西昌市人民医院新生儿科, 西昌, 615000 | |
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| 中文摘要: |
| 目的 探讨凉山地区早产儿发生新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome, NRDS)合并支气管肺发育不良(bronchopulmonary dysplasia, BPD)的危险因素，为早期临床干预提供依据。方法 回顾性分析2022年1月至2023年12月西昌市人民医院新生儿科收治的319例确诊NRDS早产儿资料，其中合并BPD 84例为观察组，其余为对照组。采用单因素与多因素logistic回归分析危险因素。结果 妊娠期高血压、妊娠期糖尿病、孕期感染、阴道出血、产检史、多胎妊娠、脐带异常、胎膜早破、宫颈机能不全、宫内窘迫及肺表面活性物质使用等因素在两组间差异有统计学意义(P＜0.05)。妊娠期高血压、妊娠期糖尿病、孕期感染、阴道出血、多胎妊娠、脐带异常、胎膜早破、宫颈机能不全及宫内窘迫为发生NRDS合并BPD的独立危险因素(P＜0.05)。结论 凉山地区早产儿NROS合并BPD受多种产前及围产期因素影响，针对这些高危因素加强管理是降低发病率的关键。 |
| 英文摘要: |
| Objective To investigate the risk factors associated with the development of bronchopulmonary dysplasia (BPD) in preterm infants diagnosed with neonatal respiratory distress syndrome (NRDS) in the Liangshan region, and to provide a scientific basis for early clinical intervention. Methods A retrospective analysis was conducted on 319 preterm infants diagnosed with NRDS admitted to the neonatal department of Xichang People′s Hospital from January 2022 to December 2023. Among them, 84 infants who developed BPD were assigned to the observation group, while the remaining 235 infants served as the control group. Univariate and multivariate logistic regression analyses were used to identify potential risk factors. Results Univariate analysis showed that gestational hypertension, gestational diabetes mellitus, prenatal infections, vaginal bleeding, antenatal care history, multiple pregnancies, umbilical cord abnormalities, premature rupture of membranes, cervical insufficiency, intrauterine distress, invasive mechanical ventilation, and surfactant administration were significantly associated with the development of BPD and the differences are statistically significant between the two groups(P < 0.05). Multivariate logistic regression identified gestational hypertension, gestational diabetes mellitus, prenatal infections, vaginal bleeding, multiple pregnancies, umbilical cord abnormalities, premature rupture of membranes, cervical insufficiency, and intrauterine distress as independent risk factors (P < 0.05). Conclusion In the Liangshan region, NRDS complicated by BPD in pretern infants is shaped by multiple antenated and perinatal factors, and strengthening management of these high-risk factors is crucial for reducing the incidence rate. |
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