| 黄丽华,刘芳,谢珊珍,林飞宁.IL-6-634位点基因多态性对冠心病合并HFrEF1年预后的预测价值[J].济宁医学院学报,2025,48(5):390-394 |
| IL-6-634位点基因多态性对冠心病合并HFrEF1年预后的预测价值 |
| The predictive value of IL-6-634 locus gene polymorphism for the 1-yearprognosis in patients with coronary heart disease with HFrEF |
| 投稿时间：2024-11-21 |
| DOI：10.3969/j.issn.1000-9760.2025.05.002 |
| 中文关键词: 白细胞介素6;基因多态性;射血分数降低型心力衰竭;预后 |
| 英文关键词: Interleukin-6;Gene polymorphisms;Heart failure with reduced ejection fraction;Prognosis |
| 基金项目:福建省自然科学基金项目(2023J01830) |
| 作者 | 单位 | E-mail | | 黄丽华 | 福建中医药大学附属人民医院检验科, 福州, 350004 | | | 刘芳 | 福建中医药大学附属人民医院检验科, 福州, 350004 | | | 谢珊珍 | 福建中医药大学附属人民医院检验科, 福州, 350004 | | | 林飞宁 | 福建中医药大学附属人民医院心血管科, 福州, 350004 | fqlfn@163.com |
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| 中文摘要: |
| 目的 探讨白细胞介素6(IL-6)-634位点基因多态性对冠心病合并射血分数降低型心力衰竭(HFrEF)1年预后的预测价值。方法 选取2022年1月至2023年12月于福建中医药大学附属人民医院心血管科住院的冠心病合并HFrEF患者188例，采用TaqMan探针法对IL-6-634位点进行基因多态性检测，比较不同基因型(GG、GC、CC)患者的人口学特征、临床资料等基线资料，并进行12个月的随访观察，采用Kaplan-Meier生存曲线法比较三组患者1年生存率差别，Cox回归分析影响患者1年主要不良心血管事件(MACE)的危险因素。结果 最终182例患者完成研究并纳入分析(6例患者在研究开始前自愿退出)。GG基因型、GC基因型、CC基因型患者的1年的因心衰加重再住院率分别为30.8%、16.4%、9.9%(P＜0.05)，1年全因死亡率分别为19.2%、7.3%、5.0%；Kaplan-Meier生存曲线分析显示GG基因型、GC基因型、CC基因型1年生存率依次升高，组间生存曲线差异存在统计学意义(P＜0.05)。Cox回归分析显示，以CC基因型为参照，GG和GC基因型均为冠心病合并HFrEF患者1年不良预后的危险因素，携带GG基因型和GC基因型的冠心病合并HFrEF患者1年MACE的风险分别是CC基因型患者的3.23倍(95%CI：1.74~6.25)和1.94倍(95%CI：1.03~3.51)。结论 IL-6-634位点基因多态性与冠心病合并HFrEF患者1年预后有关联性，GG和GC基因型是预测冠心病合并HFrEF患者1年不良预后的独立危险因素。 |
| 英文摘要: |
| Objective To investigate the predictive value of interleukin-6 (IL-6)-634 gene polymorphisms for 1-year prognosis in patients with coronary heart disease complicated by heart failure with reduced ejection fraction (HFrEF). Methods A total of 188 patients with coronary heart disease complicated by HFrEF who were hospitalized in the department of cardiology, the People′s Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2022 to December 2023 were recruited. TaqMan probe method was used to detect the gene polymorphism of IL-6-634 locus. The demographic characteristics, clinical data and other baseline data of patients with different genotypes (GG, GC, CC) were compared, and a 12-month follow-up observation was conducted. Kaplan-Meier survival curve method was used to compare the 1-year survival rate of these three groups. Cox regression analysis was used to analyze the risk factors of 1-year major adverse cardiac events in patients with coronary heart disease and HFrEF. Results Six patients (3.19 %) voluntarily withdrew from the study, and 182 patients were finally included in the study analysis. The 1-year readmission rates of patients with GG genotype, GC genotype and CC genotype due to worsening heart failure were 30.8%, 16.4% and 9.9%.The 1-year all-cause mortality rates of the three groups were 19.2%, 7.3%, and 5.0%, respectively. Kaplan-Meier survival curve analysis showed that the 1-year survival rate of GG genotype, GC genotype and CC genotype increased in turn, and the difference in survival curve between the three groups was statistically significant (P < 0.05). Cox regression analysis showed that, compared with the CC genotype, both GG and GC genotypes were risk factors for 1-year poor prognosis in patients with coronary heart disease complicated by HFrEF. The risk of 1-year MACE in patients with GG genotype and GC genotype was 3.23 times (95%CI: 1.74~6.25) and 1.94 times (95%CI: 1.03~3.51) higher than that in patients with CC genotype. Conclusion IL-6-634 gene polymorphism is associated with 1-year prognosis in patients with coronary heart disease complicated by HFrEF. GG and GC genotypes are independent risk factors for predicting 1-year poor prognosis in these patients. |
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