| 张春梅,马俊丽.GPR37在乳腺癌代谢重编程中的作用[J].济宁医学院学报,2025,48(4):378-380 |
| GPR37在乳腺癌代谢重编程中的作用 |
| The role of GPR37 in metabolic reprogramming of breast cancer |
| 投稿时间：2025-05-18 |
| DOI：10.3969/j.issn.1000-9760.2025.04.018 |
| 中文关键词: G蛋白偶联受体37;乳腺癌;代谢重编程 |
| 英文关键词: G protein-coupled receptor 37;Breast cancer;Metabolic reprogramming |
| 基金项目:山东省医学会临床科研资金齐鲁专项(YXH2022ZX02209) |
| 作者 | 单位 | E-mail | | 张春梅 | 济宁医学院附属医院(临床医学院), 济宁 272013 | | | 马俊丽 | 济宁医学院附属医院放疗科, 济宁 272029 | mjl7846@163.com |
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| 中文摘要: |
| 乳腺癌是全球女性发病率最高的恶性肿瘤,其进展与代谢重编程密切相关。代谢重编程是肿瘤的重要特征之一,通过改变糖、脂和氨基酸代谢途径,癌细胞得以适应微环境并促进生长、转移及耐药。G蛋白偶联受体37(GPR37)最初因其在神经系统和炎症反应中的作用而被研究,但近年发现其在多种肿瘤(如乳腺癌、非小细胞肺癌和结直肠癌)中异常高表达,并与肿瘤代谢调控密切相关。GPR37可通过激活Hippo和MAPK-p38等信号通路,上调糖酵解关键酶LDHA和脂代谢酶SCD1,驱动癌症的代谢重编程。目前对于GPR37在乳腺癌代谢重编程中的具体机制仍需进一步阐明。本综述系统探讨GPR37在乳腺癌代谢重编程中的作用及机制,旨在为未来的研究提供新的视角与方向。 |
| 英文摘要: |
| Breast cancer remains the most prevalent malignancy among women worldwide,with its progression closely linked to metabolic reprogramming-a hallmark of cancer that enables tumor cells to adapt to microenvironmental stresses by altering glucose,lipid,and amino acid metabolism,thereby promoting growth,metastasis,and therapy resistance.Initially studied for its roles in neurological and inflammatory processes,G protein-coupled receptor 37 (GPR37) has recently been identified as aberrantly overexpressed in various cancers,including breast cancer,non-small cell lung cancer,and colorectal cancer,where it critically regulates tumor metabolism.Studies have shown that GPR37 can activate signaling pathways such as Hippo and MAPK-p38,thereby increasing the expression of key glycolytic enzyme LDHA and lipid-metabolizing enzyme SCD1,ultimately promoting metabolic reprogramming in cancer cells.However,the precise mechanisms underlying GPR37-mediated metabolic reprogramming in breast cancer remain incompletely understood.This review systematically explores the role and mechanisms of GPR37 in metabolic reprogramming of breast cancer,aiming to provide novel perspectives and directions for future research. |
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