| 牛静,狄东川.童年不良经历与成年抑郁症:基于多维度视角的内在机制、不良后果及干预措施研究进展[J].济宁医学院学报,2025,48(4):374-377 |
| 童年不良经历与成年抑郁症:基于多维度视角的内在机制、不良后果及干预措施研究进展 |
| Childhood adverse experiences and adult depression: research progress on intrinsic mechanisms,adverse consequences,and intervention measures based on multidimensional perspectives |
| 投稿时间：2025-01-14 |
| DOI：10.3969/j.issn.1000-9760.2025.04.017 |
| 中文关键词: 童年不良经历;抑郁症;神经生物学机制;表观遗传;干预措施 |
| 英文关键词: Adverse childhood experiences;Depression;Neurobiological mechanisms;Epigenetics;Intervention strategies |
| 基金项目: |
| 作者 | 单位 | E-mail | | 牛静 | 济宁医学院精神卫生学院, 济宁 272013 | | | 狄东川 | 山东省戴庄医院老年精神科, 济宁 272052 | dikezai@163.com |
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| 中文摘要: |
| 抑郁症研究已取得显著进展,但其与童年不良经历(ACEs)的关联机制仍未完全阐明。随着自媒体时代信息传播的加速,儿童青少年期心理创伤的暴露率上升,其成年后的心理问题呈持续甚至恶化趋势,已成为公共卫生领域的重大挑战。本综述聚焦于回顾近年来童年时期心理创伤与成年抑郁症之间相关机制、不良后果及如何干预之间的相关研究,旨在发现高危人群,建立早期预警机制,以便在个体发展早期实施预防措施,降低抑郁症的发生概率,减轻其对个人和社会的负担。 |
| 英文摘要: |
| Significant advances have been made in depression research,yet the mechanisms underlying its link with adverse childhood experiences (ACEs) remain incompletely understood.In the era of social media,the accelerated dissemination of information has heightened the visibility of childhood and adolescent psychological trauma,leading to persistent and even worsening mental health problems in adulthood.This has become a major public health challenge.This review synthesizes recent research on the mechanisms connecting childhood trauma to adult depression,its adverse outcomes,and potential interventions.Our goal is to identify high-risk populations,establish early warning systems,and implement preventive measures during critical developmental periods to reduce the incidence of depression and alleviate its burden on individuals and society. |
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