| 李忠庭,刘乃婕,王亭月,刘艳玲,尹海燕,屈艳琳.肠道菌群与血液疾病之间的因果关系:一项基于孟德尔随机化的探索性分析[J].济宁医学院学报,2025,48(4):341-346 |
| 肠道菌群与血液疾病之间的因果关系:一项基于孟德尔随机化的探索性分析 |
| The causal relationship between intestinal flora and blood diseases: an exploratory analysis based on Mendelian randomization |
| 投稿时间：2024-06-19 |
| DOI：10.3969/j.issn.1000-9760.2025.04.011 |
| 中文关键词: 肠道菌群;血液疾病;孟德尔随机化分析;因果关系 |
| 英文关键词: Intestinal flora;Blood disorders;Mendelian randomization analysis;Causality |
| 基金项目:济宁医学院大学生创新训练项目(cx2024225z) |
| 作者 | 单位 | | 李忠庭 | 济宁医学院附属医院(临床医学院), 济宁 272013 | | 刘乃婕 | 济宁医学院附属医院(临床医学院), 济宁 272013 | | 王亭月 | 济宁医学院附属医院(临床医学院), 济宁 272013 | | 刘艳玲 | 济宁医学院附属医院(临床医学院), 济宁 272013 | | 尹海燕 | 济宁医学院基础医学院, 济宁 272067 | | 屈艳琳 | 济宁医学院基础医学院, 济宁 272067 |
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| 中文摘要: |
| 目的 旨在利用两样本孟德尔随机化分析肠道菌群与血液疾病之间的关系。方法 利用孟德尔随机化的3种主要分析方法,分析肠道菌群对白血病、霍奇金淋巴瘤和再生障碍性贫血的影响。结果 Adlercreutzia属丰度升高与白血病患病风险增加有关(OR=1.001,P=0.006)。Holdemania属(OR=0.999,P=0.030)和RuminococcaceaeUCG010属(OR=0.998,P=0.030)丰度升高与白血病患病风险降低有关,Veillonella属(OR=0.396,P=0.038)、Peptococcus属(OR=0.598,P=0.026)丰度升高与霍奇金淋巴瘤风险降低有关,Bacteroidia科(OR=1.386,P=0.007)、Eubacteriumhallii属(OR=1.224,P=0.041)、FamilyⅧUCG001属(OR=1.399,P=0.010)、Bacteroidetes门(OR=1.343,P=0.029)、Intestinibacter属(OR=1.244,P=0.021)、Anaerotruncus属(OR=1.365,P=0.027)丰度升高均会引起再生障碍性贫血患病风险提高。通过敏感性分析,MR结果不存在异质性和多效性。结论 肠道微生物对白血病、霍奇金淋巴瘤和再生障碍性贫血存在一定影响。 |
| 英文摘要: |
| Objective This study was to analyze the relationship between intestinal flora and blood diseases by using two-sample Mendelian randomization. Methods Three main methods of Mendelian randomization were used to analyze the effects of intestinal flora on leukemia,lymphoma and aplastic anemia. Results Increased abundance of Adlercreutzia was associated with an increased risk of leukemia (OR=1.001,P=0.006). Increased abundance in Holdemania (OR=0.999,P=0.030) and RuminococcaceaeUCG010 (OR=0.998,P=0.030) was associated with reduced risk of leukemia,and the higher abundance of Veillonella (OR=0.998,P=0.038) and Peptococcus (OR=0.598,P=0.026) was correlated with the lower risk of Hodgkin lymphoma. Elevated level of Bacteroidia (OR=1.386,P=0.007) and Eubacteriumhallii (OR=1.224,P=0.041),FamilyⅧUCG001 (OR=1.399,P=0.010),Bacteroidetes (OR=1.343,P=0.029),Intestinibacter (OR=1.244,P=0.021) and Anaerotruncus (OR=1.365,P=0.027) were associated with an increased risk of aplastic anemia.Sensitivity analysis confirmed no heterogeneity or pleiotropy in the Mendelian randomization results. Conclusion Intestinal microbiota has certain influence on leukemia, lymphoma and aplastic anemia. |
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