| 张文欢,姜云璐.Apelin/APJ系统:神经退行性疾病的潜在治疗靶点[J].济宁医学院学报,2025,48(3):268-272 |
| Apelin/APJ系统:神经退行性疾病的潜在治疗靶点 |
| Apelin/APJ system:potential therapeutic target for neurodegenerative diseases |
| 投稿时间：2023-06-05 |
| DOI：10.3969/j.issn.1000-9760.2025.03.017 |
| 中文关键词: 阿尔茨海默病;帕金森疾病;亨廷顿舞蹈症;Apelin/APJ系统;神经退行性疾病 |
| 英文关键词: Alzheimer's disease;Parkinson's disease;Huntington's disease;Apelin/APJ system;Neurodegenerative disease |
| 基金项目:山东省医药卫生科技发展计划项目(202102080596);山东省大学生创新训练计划项目(S202210443021);济宁医学院大学生创新训练计划项目(cx2022027z) |
| 作者 | 单位 | | 张文欢 | 济宁医学院神经生物学研究所, 济宁 272067 | | 姜云璐 | 济宁医学院神经生物学研究所, 济宁 272067 |
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| 中文摘要: |
| 阿尔茨海默病(Alzheimer's disease,AD)、帕金森症(Parkinson's disease,PD)与亨廷顿舞蹈症(Huntington's disease,HD)是目前无法治愈的神经退行性疾病,严重威胁着老年人的生活质量和寿命。Apelin是apelin受体(APJ)内源性配体之一,广泛分布于中枢神经系统(central nervous system,CNS)的神经元中。研究表明,Apelin/APJ表达水平的变化与神经元结构或功能的丧失、炎症反应、氧化应激、钙信号、凋亡与自噬等多种生理活动密切相关。本综述针对其在AD、PD、HD等神经系统疾病的研究进展做一综述。 |
| 英文摘要: |
| Alzheimer's disease (AD),parkinson's disease (PD) and huntington's disease (HD) are currently incurable neurodegenerative diseases,which construct a serious threat to the life quality of aging populations and their life spans.Apelin is one of the endogenous ligands of apelin receptor(APJ),which is widely distributed in neurons of the central nervous system (CNS).Studies have shown that the changes in the expression level of Apelin/APJ are closely related to the loss of neuronal structure or function,inflammatory reaction,oxidative stress,calcium signal,apoptosis,autophagy and other physiological activities.In this review,we reviewed the research progress of AD,PD,HD and other neurological diseases. |
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