| 胡广云,孟欣.沙库巴曲缬沙坦联合苯磺酸氨氯地平对原发性高血压患者血管内皮功能的影响[J].济宁医学院学报,2025,48(3):244-247 |
| 沙库巴曲缬沙坦联合苯磺酸氨氯地平对原发性高血压患者血管内皮功能的影响 |
| The effect of sacubitril/valsartan combined with amlodipine on endothelial function in patients with primary hypertension |
| 投稿时间：2025-02-12 |
| DOI：10.3969/j.issn.1000-9760.2025.03.012 |
| 中文关键词: 原发性高血压 苯磺酸氨氯地平 沙库巴曲缬沙坦 血管内皮功能 |
| 英文关键词: Primary hypertension Amlodipine besylate Sacubitril/valsartan Endothelial function of blood vessels |
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| 中文摘要: |
| 目的 采用沙库巴曲缬沙坦联合苯磺酸氨氯地平治疗原发性高血压,探究其血压控制效果及对血管内皮功能的影响。方法 选择2022年8至2024年8月收治的60例原发性高血压患者随机分为两组。对照组(n=30)仅接受苯磺酸氨氯地平治疗;观察组(n=30)接受沙库巴曲缬沙坦联合苯磺酸氨氯地平治疗。两组患者均服药8周。结果 观察组患者收缩压及舒张压均低于对照组(t=3.664,3.605,P＜0.05)。治疗8周后,观察组患者NO高于对照组,ET-1和AngII低于对照组(t=3.041,9.072,5.388,P＜0.05)。两组患者总不良反应比较差异无统计学意义(χ2=2.098,P＞0.05)。结论 沙库巴曲缬沙坦联合苯磺酸氨氯地平治疗原发性高血压效果确切,能提升改善血管内皮功能,且联合用药安全可靠。 |
| 英文摘要: |
| Objective To investigate the blood pressure control effect and its impact on endothelial function and hemorheology of patients with primary hypertension treated with sacubitril/valsartan combined with amlodipine.Method Sixty patients with primary hypertension admitted from August 2022 to August 2024 were divided into two groups.The control group (n=30) only received treatment with amlodipine besylate;The observation group (n=30) received treatment with sacubitril/valsartan and amlodipine besylate.Both groups of patients took medication for 8 weeks.Result After 8 weeks of treatment,both systolic and diastolic blood pressure in the observation group were lower (t=3.664,3.605,P＜0.05).After 8 weeks of treatment,the observation group had higher levels of NO,and lower levels of ET-1 and AngII than the control group (t=3.041,9.072,5.388,P＜0.05).There was no significant difference in the total adverse reactions between the two groups of patients (χ2=2.098,P＞0.05).Conclusion The combination of sacubitril/valsartan with amlodipine is effective in treating primary hypertension,improving endothelial function.The combination therapy is safe and reliable. |
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