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| IL-6-634位点基因多态性对缺血性心力衰竭1年预后的预测价值 |
| The Predictive Value of IL-6-634 Gene Polymorphisms in the Prognostic Effect of 1-year Prognosis in Ischemic Heart Failure |
| 投稿时间：2024-11-21 修订日期：2025-03-10 |
| DOI： |
| 中文关键词: 白细胞介素6; 基因多态性;冠心病;射血分数降低型心力衰竭;预后 |
| 英文关键词: interleukin-6, gene polymorphisms, heart failure with reduced ejection fraction, coronary heart disease, prognosis |
| 基金项目:福建省自然科学基金(2023J01830) |
| 作者 | 单位 | 邮编 | | | 福建中医药大学附属人民医院检验科 | 350004 | | 刘芳 | 福建中医药大学附属人民医院检验科 | | | 谢珊珍 | 福建中医药大学附属人民医院检验科 | | | 林飞宁* | 福建中医药大学附属人民医院心血管科 | 350004 |
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| 中文摘要: |
| 目的：探讨白细胞介素6（IL-6）-634位点基因多态性与缺血性心力衰竭1年预后的预测价值。方法：选取2022年1月至2023年12月于福建中医药大学附属人民医院心血管科住院的冠心病HFrEF患者188例，采用TaqMan探针法对IL-6-634位点进行基因多态性检测，比较不同基因型（GG、GC、CC）患者的人口学特征、临床资料等基线资料，并进行12个月的随访观察，采用 Kaplan-Meier 生存曲线法比较三组患者1年生存率差别，Cox 回归分析影响缺血性心力衰竭患者1年主要不良心脏事件的危险因素。结果：最终182例患者完成研究并纳入分析（6例患者在研究开始前自愿退出）。GG基因型、GC基因型、CC基因型三组患者的1年的因心衰加重再住院率分别为30.8%、16.4%、9.9%（P<0.05 )，1年全因死亡率分别为19.2%、7.3%、5.0%； Kaplan-Meier生存曲线分析显示GG基因型、GC基因型、CC基因型1年生存率依次降低，三组间生存曲线差异存在统计学意义（P<0.05 )。Cox回归分析显示GG和GC基因型均为缺血性心力衰竭患者1年不良预后的危险因素，携带 GG基因型和GC 基因型的缺血性心力衰竭患者1年MACE的风险分别是 CC基因型患者的3.23倍（95%CI：1.74-6.25）和1.94倍（95%CI：1.03-3.51）。结论：IL-6-634位点基因多态性与缺血性心力衰竭患者1年预后相关，GG和GC基因型是预测缺血性心力衰竭患者1年不良预后的独立危险因素。 |
| 英文摘要: |
| Objective To investigate t the predictive value of interleukin-6 (IL-6)-634 gene polymorphisms for 1-year prognosis in patients with ischemic heart failure. Methods A total of 188 patients with coronary heart disease and heart failure with reduced ejection fraction (HFrEF) who were discharged from the Department of Cardiology, Fujian Provincial People 's Hospital from January 2022 to December 2023 were recruited. TaqMan probe method was used to detect the gene polymorphism of IL-6-634 locus. The demographic characteristics, clinical data and other baseline data of patients with different genotypes (GG, GC, CC) were compared, and 12-month follow-up observation was conducted. Kaplan-Meier survival curve method was used to compare the 1-year survival rate of these three groups. Cox regression analysis was used to analyze the risk factors of 1-year major adverse cardiac events in patients with coronary heart disease and HFrEF. Results Six patients (3.19 %) voluntarily withdrew from the study, and 182 patients were finally included in the study analysis. The 1-year readmission rates of patients with GG genotype, GC genotype and CC genotype were 30.8 %, 16.4 % and 9.9 %, respectively. Kaplan-Meier survival curve analysis showed that the 1-year survival rate of GG genotype, GC genotype and CC genotype decreased in turn, and the difference in survival curve between the three groups was statistically significant (P < 0.05). Cox regression analysis showed that both GG and GC genotypes were risk factors for 1-year poor prognosis in patients with coronary heart disease and HFrEF. The risk of 1-year MACE in patients with GG genotype and GC genotype was 3.23 times (95 % CI: 1.74-6.25) and 1.94 times (95 % CI: 1.03-3.51) higher than that in patients with CC genotype. Conclusion IL-6-634 gene polymorphism is associated with 1-year prognosis in patients with ischemic heart failure. GG and GC genotypes are independent risk factors for predicting 1-year poor prognosis in patients with ischemic heart failure. |
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