|
| 自身免疫性疾病与多发性骨髓瘤孟德尔随机化研究 |
| Mendelian Randomization study of autoimmune diseases and multiple myeloma |
| 投稿时间：2024-08-12 修订日期：2025-09-03 |
| DOI： |
| 中文关键词: 类风湿性关节炎；甲状腺功能减退症；多发性骨髓瘤；因果关联；孟德尔随机化 |
| 英文关键词: Rheumatoid arthritis; hypothyroidism； Multiple myeloma; Causality; Mendenlian randomization study |
| 基金项目:济宁医学院大学生创新训练计划项目 |
| 作者 | 单位 | 邮编 | | 王永茹 | 济宁医学院临床医学院 | 272067 | | 刘乃婕 | 济宁医学院临床医学院 | | | 王亭月 | 济宁医学院临床医学院 | | | 刘艳玲 | 济宁医学院临床医学院 | | | 孔涵* | 济宁医学院基础医学院机能学实验室 | 272067 |
|
| 摘要点击次数: 0 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：通过孟德尔随机化分析方法探究9种自身免疫性疾病与多发性骨髓瘤的因果关系，并进行多变量孟德尔随机化分析，为多发性骨髓瘤的临床治疗研究提供新思路。
方法：从已发表的全基因组关联研究中选择了9个自身免疫性疾病，提取这些自身免疫性疾病的SNP作为工具变量。通过双样本和多变量孟德尔随机化分析，来评估自身免疫性疾病与多发性骨髓瘤的因果关系，逆方差加权法(IVW)作为主要的分析方法，使用加权中位数、加权模式法、MR-Egger回归等方法对结果进行异质性检验、多效性检验和敏感性分析。
结果：逆方差加权法分析结果显示，甲状腺功能减退症(OR= 0.548 ，95%CI: 0.347~0.866, P=0.010)和类风湿性关节炎(OR=0.972,95%CI: 0.954~0.991, P=0.005)与多发性骨髓瘤皆呈负向因果关系。敏感性分析结果表明结果稳健，MR-Egger截距分析未检测到潜在的水平多效性。多变量孟德尔随机化结果显示，甲状腺功能减退症与多发性骨髓瘤的因果关联不显著，类风湿性关节炎对多发性骨髓瘤有直接的负向因果关系。反向孟德尔随机化显示，不存在反向因果关系。类风湿性关节炎与多发性骨髓瘤可能存在负向因果关系。
结论：类风湿性关节炎与多发性骨髓瘤之间可能存在负向因果关系，且独立作用于多发性骨髓瘤的发病。 |
| 英文摘要: |
| Objective: To explore the causal relationship between nine autoimmune diseases and multiple myeloma by Mendelian randomization analysis method with multivariate Mendelian randomization analysis, and to provide new ideas for the clinical treatment research of multiple myeloma.
Methods: Nine autoimmune diseases were selected from published genome-wide association studies and SNPs of these autoimmune diseases were extracted as instrumental variables. Two-sample and multivariate Mendelian randomization analyses were used to assess the causal relationship between autoimmune diseases and multiple myeloma, with inverse variance weighting (IVW) as the primary analytical method, and heterogeneity tests, multiple validity tests, and sensitivity analyses of the results were performed using the weighted median, the weighted mode method, and MR-Egger regression.
Results: The results of the inverse variance weighting method analysis showed a negative causal relationship between both hypothyroidism (OR= 0.548, 95% CI: 0.347~0.866, P=0.010) and rheumatoid arthritis (OR=0.972,95% CI: 0.954~0.991, P=0.005) and multiple myeloma. Sensitivity analyses showed robust results, and MR-Egger intercept analysis did not detect potential horizontal pleiotropy. Multivariate Mendelian randomization showed a non-significant causal association between hypothyroidism and multiple myeloma, and a direct negative causal association between rheumatoid arthritis and multiple myeloma. Reverse Mendelian randomization showed no reverse causality. There may be a negative causal association between rheumatoid arthritis and multiple myeloma.
Conclusion: There may be a negative causal relationship between rheumatoid arthritis and multiple myeloma and an independent role in the development of multiple myeloma. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
|
|
|
