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| 肠道菌群与血液疾病之间的因果关系：一项基于孟德尔随机化的探索性分析 |
| The causal relationship between intestinal flora and some blood diseases was analyzed based on Mendelian randomization |
| 投稿时间：2024-06-19 修订日期：2025-05-18 |
| DOI： |
| 中文关键词: 肠道菌群；血液疾病；孟德尔随机化分析；因果关系 |
| 英文关键词: intestinal flora; Blood disorders; Mendelian randomization analysis; causality |
| 基金项目:国家自然科学基金项目，济宁医学院大学生创新训练项目 |
| 作者 | 单位 | 邮编 | | 李忠庭 | 济宁医学院临床医学院 | 272067 | | 刘乃婕 | 济宁医学院临床医学院 | | | 王亭月 | 济宁医学院临床医学院 | | | 刘艳玲 | 济宁医学院临床医学院 | | | 尹海燕 | 济宁医学院基础医学院 | | | 屈艳琳* | 济宁医学院基础医学院 | 272067 |
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| 中文摘要: |
| 目的 本研究旨在利用两样本孟德尔随机化分析肠道菌群与血液疾病之间的关系。方法 我们采用逆方差加权法（IVW）、MR-Egger回归法和加权中位数法（Weighted median），分析肠道菌群对白血病、淋巴瘤和再生障碍性贫血的影响。结果 研究发现，Adlercreutzia属丰度的升高与白血病患病风险增加相关。Holdemania属和RuminococcaceaeUCG010属丰度的升高与白血病患病风险降低相关，CandidatusSoleaferrea纲、Veillonella属、Peptococcus属的丰度升高与霍奇金淋巴瘤风险增加相关，Actinobacteria科丰度的升高与霍奇金淋巴瘤患病风险降低相关。Bacteroidia科、Eubacteriumhalliigroup属、FamilyXIIIUCG001属、Bacteroidetes门、Intestinibacter属、Anaerotruncus属的丰度升高均会引起再生障碍性贫血患病风险提高。结论 肠道微生物对白血病、淋巴瘤和再生障碍性贫血存在一定的影响。 |
| 英文摘要: |
| Objective The aim of this study was to analyze the relationship between intestinal flora and blood diseases by using two-sample Mendelian randomization. Methods Inverse variance Weighted method (IVW), MR-Egger regression method and Weighted median method were used to analyze the effect of intestinal flora on leukemia, lymphoma and aplastic anemia. Results Increased abundance of Adlercreutzia was associated with an increased risk of leukemia. The increased abundance of Holdemania and RuminococcaceaeUCG010 genera is associated with a decreased risk of leukemia, while the increased abundance of CandidatusSoleaferrea, Veillonella and Peptococcus genera is associated with an increased risk of Hodgkin's lymphoma. The increased abundance of Actinobacteria is associated with a reduced risk of Hodgkin's lymphoma. An increase in the abundance of Bacteroidia, Eubacteriumhalliigroup, FamilyXIIIUCG001, Bacteroidetes, Intestinibacter, and Anaerotruncus will cause aplasia Risk increased. Conclusion Intestinal microbiota has certain influence on leukemia, lymphoma and aplastic anemia. |
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