| 齐浩然,曹贝,曹敏,王凯.酞菁铜催化的8-氨基喹啉选择性C (sp2)-O偶联反应[J].济宁医学院学报,2024,47(1):1-4 |
| 酞菁铜催化的8-氨基喹啉选择性C (sp2)-O偶联反应 |
| Copper(Ⅱ) phthalocyanine-catalyzed selective C(sp2)-O cross-coupling reactions of 8-aminoquinoline |
| 投稿时间：2023-11-18 |
| DOI：10.3969/j.issn.1000-9760.2024.01.001 |
| 中文关键词: 非均相催化 酞菁铜 8-氨基喹啉 C-O偶联反应 |
| 英文关键词: Heterogeneous catalysis Copper phthalocyanine 8-Aminoquinoline C-O cross coupling reaction |
| 基金项目:济宁医学院大学生创新训练计划（CX20220352） |
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| 中文摘要: |
| 目的 开发一种应用非均相催化体系的8-氨基喹啉衍生物选择性C-O键构建方法。方法 分别从催化剂及氧化剂等对反应进行优化，并以筛选出的最优条件展开底物普适性考察。结果 以酞菁铜作为催化剂，碘苯二乙酸为氧化剂，于50℃下在乙酸中反应5h，高效实现了8-氨基喹啉C5-H选择性C-O键构建。结论 成功开发了一种应用非均相催化体系的C-O键构建方法并将其应用于8-氨基喹啉C5-H选择性官能团化。 |
| 英文摘要: |
| Objective Developing a heterogeneous catalysis system for the selective C5(sp2)-O cross coupling of 8-aminoquinoline derivatives.Methods Optimizing the reaction from catalysts and oxidants, the scope of substrates was then investigated via the optimal conditions.Results With copper phthalocyanine as catalyst and PhI(OAC) 2 as oxidant, C5 selective C-O bond was efficiently constructed in AcOH at 50℃ for 5h.Conclusion A method for C-O bond construction by means of heterogeneous catalytic system was successfully developed and applied to the selective functionalization of 8-aminoquinoline derivatives. |
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